Caseous lymphadenitis by Corynebacterium pseudotuberculosis in a Saanen dairy goat (Capra hircus aegagrus)

Corynebacterium pseudotuberculosis에 의한 유산양의 가성결핵 증례

  • 신동호 (국립수의과학검역원 질병진단센터) ;
  • 송윤경 (국립수의과학검역원 질병진단센터) ;
  • 변재원 (국립수의과학검역원 질병진단센터) ;
  • 김하영 (국립수의과학검역원 질병진단센터) ;
  • 김형순 (국립수의과학검역원 질병진단센터) ;
  • 우계형 (국립수의과학검역원 질병진단센터) ;
  • 이오수 (국립수의과학검역원 질병진단센터) ;
  • 정병일 (국립수의과학검역원 질병진단센터)
  • Accepted : 2009.12.17
  • Published : 2010.03.30

Abstract

Caseous lymphadenitis (CLA) is a chronic and contagious disease of sheep and goats caused by Corynebacterium (C.) pseudotuberculosis. A four-year-old female Saanen dairy goat was submitted to the Animal Disease Diagnostic Center at National Veterinary Research and Quarantine Service. The clinical signs of the goat were emaciation, abortion and quadriplegia. The multifocal nodules of lymph nodes were encapsulated and filled with whitish caseous contents on the cut surface. Histopathologically, lymph nodes displayed suppurative and necrotizing granulomas. Caseous necrosis was diffusely observed in the center of the lymph nodes. Gram positive bacilli were shown in the lesions. C. pseudotuberculosis was isolated and confirmed by the biochemical tests and PCR assay. Based on clinical signs, histopathological examination and bacterial isolation, we diagnosed this case as CLA. To our knowledge, this is the first report of CLA in a Saanen dairy goat in Korea.

Acknowledgement

Supported by : 국립수의과학검역원

References

  1. 농림수산식품부. 농림통계연보. p. 131, 농림수산식품부, 과천, 2007
  2. 최원필, 송희종, 김순재. 수의전염병학. 3판. pp. 161-163, 경북대학교 출판부, 대구, 2005
  3. Baird GJ, Fontaine MC. Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis. J Comp Pathol 2007, 137, 179-210 https://doi.org/10.1016/j.jcpa.2007.07.002
  4. Brown CC, Olander HJ. Caseous lymphadenitis of goats and sheep: a review. Vet Bull 1987, 57, 1-12
  5. Cetinkaya B, Karahan M, Atil E, Kalin R, de Baere T, Vaneechoutte M. Identification of Corynebacterium pseudotuberculosis isolates from sheep and goats by PCR. Vet Microbiol 2002, 88, 75-83 https://doi.org/10.1016/S0378-1135(02)00089-5
  6. Connor KM, Quirie MM, Baird G, Donachie W. Characterization of United Kingdom isolates of Corynebacterium pseudotuberculosis using pulsed-field gel electrophoresis. J Clin Microbiol 2000, 38, 2633-2637
  7. Goldberger AC, Lipsky BA, Plorde JJ. Suppurative granulomatous lymphadenitis caused by Corynebacterium ovis (pseudotuberculosis). Am J Clin Pathol 1981, 76, 486-490 https://doi.org/10.1093/ajcp/76.4.486
  8. House RW, Schousboe M, Allen JP, Grant CC. Corynebacterium ovis (pseudotuberculosis) lymphadenitis in a sheep farmer: a new occupational disease in New Zealand. N Z Med J 1986, 99, 659-662
  9. Menzies PI, Hwang YT, Prescott JF. Comparison of an interferon-gamma to a phospholipase D enzymelinked immunosorbent assay for diagnosis of Corynebacterium pseudotuberculosis infection in experimentally infected goats. Vet Microbiol 2004, 100, 129-137 https://doi.org/10.1016/j.vetmic.2004.01.012
  10. Miers KC, Ley WB. Corynebacterium pseudotuberculosis infection in the horse: study of 117 clinical cases and consideration of etiopathogenesis. J Am Vet Med Assoc 1980, 177, 250-253
  11. Pacheco LGC, Pena RR, Castro TLP, Dorella FA, Bahia RC, Carminati R, Frota MN, Oliveira SC, Meyer R, Alves FSF, Miyoshi A, Azevedo V. Multiplex PCR assay for identification of Corynebacterium pseudotuberculosis from pure cultures and for rapid detection of this pathogen in clinical samples. J Med Microbiol 2007, 56, 480-486 https://doi.org/10.1099/jmm.0.46997-0
  12. Paton MW, Mercy AR, Wilkinson FC, Gardner JJ, Sutherland SS, Ellis TM. The effects of caseous lymphadenitis on wool production and body weight in young sheep. Aust Vet J 1988, 65, 117-119 https://doi.org/10.1111/j.1751-0813.1988.tb14429.x
  13. Paton MW, Rose IR, Hart RA, Sutherland SS, Mercy AR, Ellis TM, Dhaliwal JA. New infection with Corynebacterium pseudotuberculosis reduces wool production. Aust Vet J 1994, 71, 47-49 https://doi.org/10.1111/j.1751-0813.1994.tb06152.x
  14. Paton MW, Walker SB, Rose IR, Watt GF. Prevalence of caseous lymphadenitis and usage of caseous lymphadenitis vaccines in sheep flocks. Aust Vet J 2003, 81, 91-95 https://doi.org/10.1111/j.1751-0813.2003.tb11443.x
  15. Peel MM, Palmer GG, Stacpoole AM, Kerr TG. Human lymphadenitis due to Corynebacterium pseudotuberculosis: report of ten cases from Australia and review. Clin Infect Dis 1997, 24, 185-191 https://doi.org/10.1093/clinids/24.2.185
  16. Pekelder JJ. Caseous lymphadenitis. In: Martin WB, Aitken ID (eds.). Diseases of Sheep. 3rd ed. pp. 270-274, Blackwell, Oxford, 2000
  17. Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. 10th ed. pp. 795-798, Saunders, New York, 2007
  18. Songer JG, Beckenbach K, Marshall MM, Olson GB, Kelley L. Biochemical and genetic characterization of Corynebacterium pseudotuberculosis. Am J Vet Res 1988, 49, 223-226
  19. Williamson LH. Caseous lymphadenitis in small ruminants. Vet Clin North Am Food Anim Pract 2001, 17, 359-371 https://doi.org/10.1016/S0749-0720(15)30033-5
  20. Yeruham I, Elad D, Van-Ham M, Shpigel NY, Perl S. Corynebacterium pseudotuberculosis infection in Israeli cattle: clinical and epidemiological studies. Vet Rec 1997, 140, 423-427 https://doi.org/10.1136/vr.140.16.423