Application of thromboxane synthetase inhibitor (Ozagrel HCl) in feline infectious peritonitis

고양이 전염성 복막염에 thromboxane synthetase inhibitor (Ozagrel HCl)의 적용

  • Kim, Tae-Sin (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Sun-Hee (College of Veterinary Medicine, Chungnam National University) ;
  • Lim, Soo-Jung (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Hyung-Jin (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Eun-Sik (College of Veterinary Medicine, Chungnam National University) ;
  • Jung, Dae-Wook (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Duck-Hwan (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (College of Veterinary Medicine, Chungnam National University)
  • 김태신 (충남대학교 수의과대학) ;
  • 이선희 (충남대학교 수의과대학) ;
  • 임수정 (충남대학교 수의과대학) ;
  • 박형진 (충남대학교 수의과대학) ;
  • 송은식 (충남대학교 수의과대학) ;
  • 정대욱 (충남대학교 수의과대학) ;
  • 김덕환 (충남대학교 수의과대학) ;
  • 송근호 (충남대학교 수의과대학)
  • Accepted : 2010.03.03
  • Published : 2010.03.30

Abstract

A Persian chinchila (2 years old, intact female) and a Korean domestic shorthaired cat (3 months, intact male) were referred to the Veterinary Medical Teaching Hospital of Chungnam National University with tachypnea. The two cats were diagnosed as feline infectious peritonitis (FIP) by blood and blood chemical examination, radiographic examination, RT-PCR and electrophoresis analysis of pleural effusion. Thromboxane synthetase inhibitor (Ozagrel HCl, 5 mg/kg, twice a day) was administered to the Persian chinchila and Korean domestic shorthair for 13 days and 16 days, respectively. Pleural effusion disappeared after treatment with Ozagrel HCl. Further study is needed to establish a new application protocol of Ozagrel HCl for FIP cases.

References

  1. Birchard SJ, Sherding RG. Saunders Manual of Small Animal Practice. 3rd ed. pp. 132-143, Saunders, St. Louis, 2006
  2. Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 6th ed. pp. 663-666, Saunders, St. Louis, 2005
  3. Hartmann K. Feline infectious peritonitis. Vet Clin North Am Small Anim Pract 2005, 35, 39-79 https://doi.org/10.1016/j.cvsm.2004.10.011
  4. Herrewegh AAPM, de Groot RJ, Cepica A, Egberink HF, Horzinek MC, Rottier PJM. Detection of feline coronavirus RNA in feces, tissues, and body fluids of naturally infected cats by reverse transcriptase PCR. J Clin Microbiol 1995, 33, 684-689
  5. Morgan RV. Handbook of Small Animal Practice. 5th ed. pp. 1093-1095. Saunders, St. Louis, 2008
  6. Nelson RW, Couto CG. Small Animal Internal Medicine. 4th ed. pp. 1338-1341, Mosby, St. Louis, 2009
  7. Nyland TG, Matton JS. Small Animal Diagnostic Ultrasound. 2nd ed. pp. 334-353, Saunders. St. Louis, 2002
  8. Pedersen NC. A review of feline infectious peritonitis virus infection: 1963-2008. J Feline Med Surg 2009, 11, 225-258 https://doi.org/10.1016/j.jfms.2008.09.008
  9. Thrall DE. Handbook of Veterinary Diagnostic Radiology. 5th ed. pp. 555-567, Saunders, St. Louis, 2007
  10. Watari T, Kaneshima T, Tsujimoto H, Ono K, Hasegawa A. Effect of thromboxane synthetase inhibitor on feline infectious peritonitis in cats. J Vet Med Sci 1998, 60, 657-659 https://doi.org/10.1292/jvms.60.657