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Effects of Dietary Betaine on the Secretion of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-1 and -3 in Laying Hens

  • Choe, H.S. (Division of Animal Science & Biotechnology, College of Agriculture and Life Science, Chonbuk National University) ;
  • Li, H.L. (College of Agriculture, Yanbian University) ;
  • Park, J.H. (Division of Animal Science & Biotechnology, College of Agriculture and Life Science, Chonbuk National University) ;
  • Kang, C.W. (Department of Physiology, College of Veterinary Medicine, Chonbuk National University) ;
  • Ryu, Kyeong Seon (Division of Animal Science & Biotechnology, College of Agriculture and Life Science, Chonbuk National University)
  • Received : 2007.11.07
  • Accepted : 2008.12.24
  • Published : 2010.03.01

Abstract

The principal objective of this experiment was to determine the effects of dietary betaine on IGF-I, IGFBP-3 and IGFBP-1 secretion and IGF-I mRNA gene expression in the serum and liver of laying hens. A total of 72 ISA-Brown laying hens were fed with four different levels of betaine (0, 300, 600, 1,200 ppm) based on a corn-soybean meal diet containing 2,800 kcal/kg of metabolizable energy (ME) and 16% crude protein (CP) for four weeks. The results indicated significantly higher serum and liver IGF-I concentrations in the laying hens fed with 600 and 1,200 ppm betaine (p<0.05) compared to controls. IGF-I gene expression in liver showed a statistically correlated increase in 600 and 1,200 ppm betaine-fed groups as compared to the controls (p<0.05). Serum IGFBP-3 concentrations were elevated significantly in the groups fed 600 ppm of betaine. However, the secretion of IGFBP-1 in the liver of laying hens fed on 600 and 1,200 ppm of betaine was significantly lower than in the controls (p<0.05). The results of this experiment showed that dietary betaine supplementation plays a pivotal role in changes of the IGFs system in laying hens.

Keywords

Betaine;Laying Hens;Insulin-like Growth Factor-I;Insulin-like Growth Factor Binding Protein;IGF-I mRNA Gene Expression

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