Anti-obesity effects of onion juice in high fat diet-induced obese rats

비만 유도 흰쥐에 대한 양파의 항비만 효과

  • Kang, Won Young (College of Veterinary Medicine, Jeju National University) ;
  • Kim, Mun Yong (College of Veterinary Medicine, Jeju National University) ;
  • Jin, Ju Youn (College of Veterinary Medicine, Jeju National University) ;
  • Yang, Heekyoung (College of Veterinary Medicine, Jeju National University) ;
  • Hong, Hyun Ju (College of Veterinary Medicine, Jeju National University) ;
  • Kim, Dong Geon (College of Veterinary Medicine, Jeju National University) ;
  • Han, Chang-Hoon (College of Veterinary Medicine, Jeju National University) ;
  • Lee, Young Jae (College of Veterinary Medicine, Jeju National University)
  • 강원영 (제주대학교 수의과대학) ;
  • 김문용 (제주대학교 수의과대학) ;
  • 진주연 (제주대학교 수의과대학) ;
  • 양희경 (제주대학교 수의과대학) ;
  • 홍현주 (제주대학교 수의과대학) ;
  • 김동건 (제주대학교 수의과대학) ;
  • 한창훈 (제주대학교 수의과대학) ;
  • 이영재 (제주대학교 수의과대학)
  • Accepted : 2010.01.11
  • Published : 2010.03.30

Abstract

This study investigated the effects of onion juice on the serum lipid components and blood pressure in obese rats fed high fat diets. Thirty-nine of Sprague-Dawley rats were divided into six groups, and were treated for 8 weeks: (1) normal diet (ND); (2) high fat diet (HFD); (3) HFD for first 4 weeks and high fat diet with 40% onion juice for the last 4weeks (H-H+O); (4) HFD with 40% onion juice for 8 weeks (H+O); (5) HFD for first 4 weeks and ND for the last 4 weeks (H-N); (6) HFD for first 4 weeks and ND with 40% onion juice for the last 4 weeks (H-N+O). The rates of increasing body weight were reduced in H+O and H-H+O groups compared with HFD group. The levels of triglyceride, low density lipoprotein-cholesterol and total cholesterol in blood serum were significantly decreased in the H+O and H-H+O groups compared with the HFD group. Administration of onion reduced the size of adipocyte, steatosis, and serum hyperlipidemia in obese rats fed HFD. Moreover, the antihypertensive effects of onion were observed in obesity rat fed HFD. Overall results suggest that onion reduces the serum lipid components and improves hypertension in obese rat fed HFD.

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