Suppressed Fat Accumulation in Rats Fed a Histidine-Enriched Diet

  • Endo, Michiko (Department of Bioscience and Food Production Science, Interdisciplinary Graduate School of Science and Technology, Shinshu University) ;
  • Kasaoka, Seiichi (Department of Health and Nutrition, Bunkyo University Women's College) ;
  • Takizawa, Miki (Department of Health and Nutrition, Bunkyo University Women's College) ;
  • Goto, Kiyoko (Department of Health and Nutrition, Bunkyo University Women's College) ;
  • Nakajima, Shigeru (Department of Health and Nutrition, Bunkyo University Women's College) ;
  • Moon, Soo-Kyung (Department of Food and Nutrition, College of Natural Sciences, Gyeongsang National University) ;
  • Kim, In-Soo (Department of Food and Nutrition, College of Natural Sciences, Gyeongsang National University) ;
  • Jeong, Bo-Young (Department of Food and Nutrition, College of Natural Sciences, Gyeongsang National University) ;
  • Nakamura, Soichiro (Department of Bioscience and Food Production Science, Interdisciplinary Graduate School of Science and Technology, Shinshu University)
  • Published : 2010.03.31


The effect on body fat accumulation on male Wistar rats undergoing continuous feeding with a histidine-enriched diet was investigated. Five-week-age rats were assigned to two groups and were fed either the control diet (purified diet AIN-$76^{TM}$) or the histidine-enriched diet containing 3% histidine for 28 days. It was observed that both adipose tissue masses in retroperitoneal and epididymal areas of rats fed histidine-enriched diet significantly decreased (p<0.05) compared to those of control rats, while there was no significant difference in the food efficiency ratio between them. The blood levels of histidine derivatives of 3-methylhistidine and carnosine were significantly (p<0.05) increased in the rats fed a histidine-enriched diet, whereas there were no significant different between the histidine-enriched diet and control groups in the general amino acid distribution. Our results demonstrate that a histidine-enriched diet suppresses body fat accumulation in rats.


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