- Volume 39 Issue 4
DOI QR Code
Effects of Medicinal Plant Extract on the Change of Cerebral Hemodynamic in Rats
약용식물 추출물이 흰쥐의 뇌혈류학적 변화에 미치는 영향
- Park, Sung-Jin (Dept. of Tourism Food Service Cuisine, Hallym College) ;
- Hahm, Tae-Shik (Dept. of Food and Biotechnology, Hanseo University) ;
- Kim, Cheun-An (Borinara Coperation)
- Published : 2010.04.30
As an attempt to develop new functional health beverage by using medicinal herb, we investigated the effect of medicinal plant extract (MPE) on mean arterial blood pressure (MABP) and regional cerebral blood flow (rCBF) of rats. The changes of MABP and rCBF were determined by LDF methods. LDF allows for real time, noninvasive, continuous recordings of local CBF. MABP in MPE treated rats showed significant change of MPE 1.0 and 10.0 mg/kg. MPE i.v. administration showed significant increase of rCBF in a dose-dependent manner. Propranolol pretreated MABP showed significant change in the increase of MPE. rCBF of propranolol pretreated rats showed significant change from the i.v. injection concentration of 1.0 and 10.0 mg/kg. The ischemia/reperfusion induced oxidative stress may have contributed to cerebral damage in rats, and the present study provides clear evidence for the beneficial effect of MPE on ischemia induced brain injury. Also, the action mechanism in elevation effect of MPE on rCBF might be concerned with the role of
- 대한신경외과학회. 1998. 신경외과학. 중앙문화사, 서울. p 150-156.
- 이대희. 2003. 임상신경학(II. 각론). 고려대학교출판부, 서울. p 59-61.
- 이대희. 2003. 임상신경학(II. 각론). 고려대학교출판부, 서울. p 70-77.
- 김기석. 1989. 뇌. 서원사, 서울. p 49-50.
- 성호경. 1996. 생리학. 의학문화사, 서울. p 110.
- Slomiany BL. 2004. Platelet activation factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase dependent constitutive nitric oxide synthase activation. J Physiol Pharmacol 55: 85-98.
- 오건. 1952. 내과학. 남산당, 서울. p 123-127.
- 이중달. 1990. 그림으로 설명한 병리학. 고려의학, 서울. p 740-743.
- He J, Klag MJ, Whelton PK, Mo JP, Chen JY, Qian MC, Mo PS, He GQ. 1995. Oats and buckwheat intakes and cardiovascular disease risk factors in an ethnic minority of China. Am J Clin Nutr 61: 366-372. https://doi.org/10.1093/ajcn/61.2.366
- Son MJ, Cha CG, Park JH, Kim CS, Lee SP. 2005.Manufacture of dropwort extract using brown sugar, fructosesyrup and oilgosaccharides. J Korean Soc Food SciNutr 34: 1485-1489. https://doi.org/10.3746/jkfn.2005.34.9.1485
- Lee HY, Yoo MJ, Chung HJ. 2001. Antibacterial activities in watercress (Oenanthe javanica D.C.) cultivated with differentculture methods. Kor J Food Culture 16: 243-249.
- Whang TE, Lim HO, Lee JW. 1999. Effect of fermented (Oenanthe javanica D.C.) extract on the activity of enzymes related to liver function of alcohol-administered rats andmice. Kor J Medicinal Crop Sci 7: 107-114.
- Cho SY, Kim MJ. 1995. The effect of plantafinis semen on serum and hepatic lipid metabolism in fed high and low fat diets. J Korean Soc Food Nutr 24: 517-522.
Chung IM, Yun HS, Kim YS, Ahn JW. 1984. Aucubin: potential antidote for
$\alpha$-amanitin poisoning. J Toxicol Clin Toxicol 22: 77-85. https://doi.org/10.3109/00099308409035083
- Carlo B, Fabio D. 1982. Assignment of correct structure to two tetra-hydrodideoxy aucubins. J Org Chem 147: 1343-1352.
- Han SM. 2005. Studies on the functional components and cooking aptitude for medicinal tea of Chrysnathemum indicum L. PhD Dissertation. Sejong University, Seoul, Korea. p 1.
- Shin GC, Shin YC. 1992. New our talk large a dictionary. Samsung publishing Co., Seoul, Korea. p 68.
- Choi YJ. 1992. Korea folk vegetation. Academy books, Seoul, Korea. p 53.
- 신민교. 1997. 임상본초학. 영림사, 서울.
- Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD. 1986.A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 17: 738-743. https://doi.org/10.1161/01.STR.17.4.738