달팽이 점액이 아토피 피부염 환자의 피부장벽 회복에 미치는 영향

오민지;박성민;김희택
Oh, Min-Jee;Park, Sung-Min;Kim, Hee-Taek

  • 투고 : 2010.11.08
  • 심사 : 2010.12.09
  • 발행 : 2010.12.25

초록

Purposes : The object of present study is to detect the Effects of Snail Secretion Filtrate and Hyaluronic acid on the skin barrier's recovery of the Atopic dermatitis. Methods : A total of 20 patients who visited Semyung Hanny Oriental Medical Center from september 1st, 2009 to August 31th, 2010 were included in this study. In this study, they were treated with Snail Secretion Filtrate(experimental group) and Hyaluronic acid(control group). For 4 weeks gross examination, hematological examination and instrumentation through skin-ANBT equipment were made before and after the experiments to see how well the products for experimental group act against those for control group in recovering the damaged skin barriers by Atopic dermatitis. Results : 1. In the primary endpoint, SCORAD Index showed a statistically significant decline in both the control group and the experimental group. However, the experimental group showed greater statistical significance than the control group. 2. In the secondary endpoint index of skin hydration, both the control group and the experimental group did not show a statistically significant increase. However, the degree of skin hydration in the experimental group is greater than in the control group. 3. In global assessment of efficacy, it was higher in the experimental group than in the control group for both the subjects and the researchers. 4. To evaluate the safety of the products for the human body, hematological examination and hematological biochemical examination were conducted; both the control group and the experimental group showed no abnormal level. Therefore, the safety of the products, if used for so long a time, proved to be safe for the human body. 5. Product satisfaction was higher in the experimental group than in the control group. Conclusions : According to above experiments, Snail Secretion Filtrate was effective on the Atopic dermatitis.

키워드

Snail Secretion Filtrate;Hyaluronic acid;Atopic dermatitis

참고문헌

  1. 안성구, 지혜구, 황상민, 정준, 장경훈. Common skin disease. 서울:퍼시픽출판사. 2003:42-50.
  2. Hanifin JM, Rajka RG. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92(suppl. 144):44-7.
  3. 박영립, 김형동, 김규한, 김명남, 김진우, 노영석, 박천욱, 이광훈, 이애영, 조상현, 최지호. 아토피 피부염 학회보고서:한국인 아토피피부진단 기준에 대한 연구. 대한피부과학회지. 2006;44(6):659-63.
  4. Larsen FS, Hanifin JM. Secular change in the occurrence of atopic dermatitis. Acta Derm Venereol. 1992;suppl 176:7-12.
  5. 허준. 동의보감. 서울:법인 문화사. 1999:157.
  6. 김도원. 피부장벽의 손상과 회복. 한국피부장벽학회지. 2006;18(1):25-8.
  7. 유형철, 이지법, 이승철, 원영호. 아토피피부염에서 첩포시험과 경표피수분손실 측정에 의한 피부장벽기능의 연구. 천식 및 알레르기. 2000;20(5):702-9.
  8. 顧伯華. 實用中醫外科學. 上海:上海科學技術出版社. 1985:280-2.
  9. Ogawa H, Yoshiike T. A speculative view of atopic dermatitis: barrier dysfunction in pathogenesis. J Dermatol Sci. 1993;5: 197-204. https://doi.org/10.1016/0923-1811(93)90767-J
  10. Leung DYM, Rhodes A, Geha RS, Atopic dermatitis. In: Fitzpatrick T, Eisen A, Wolff, eds. Dermatology in general medicine. New york: McGrw-Hill, Inc: 1993:1543-63.
  11. Imokawa G, Abe A, Jin K, Higaki Y, et al. Decreased level of ceramides in stratum corneum of atopic dermatologic factor in atopic dry skin J Invest Dermatol. 1991 Apr;96(4):523-6. https://doi.org/10.1111/1523-1747.ep12470233
  12. Tatsuya H, An Open Clinical Trial of Glycoceramide-containing Cream and lotion on Dry skin of Atopic Dermatitis. Skin Research. 1998;40:415-9.
  13. 윤희성, 이길영, 김윤범. 蘆薈 Dressing을 활용한 급성기 아토피피부염 환자 치험 8례. 대한안이비인후피부과학회지. 2004;17(3):153-66.
  14. Stalder, J and Taieb, A. European task force on atopic dermatitis : The SCORAD index. Dermatology. 1993;186:23-31. https://doi.org/10.1159/000247298
  15. 신상호, 김미보, 변석미, 이호섭, 박선규, 고우신, 윤화정. 아토피 피부염의 외치법에 대한 고찰. 한방안이비인후피부과학회지. 2008;21(2):80-93.
  16. Efficacy and safety of tacrolimus ointment in pediatiric Patients with moderate to severe atopic dermatitis. singalavanija S, at el. J med assoc Thai. 2006 NOV;89(11):1915-22.
  17. Leung DYM, Eichenfield LF, Boquniewicz M. Atopic dermatitis, In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's dermatology in general medicine, 6th ed. New York: McGraw-Hi. 2003:1180-94.
  18. 顧伯華. 實用中醫外科學. 上海:上海科學技術出版社. 1996:460-4.
  19. 박민철, 김진만, 홍철희, 황충연. 아토피 피부염의 동서의학적 문헌 고찰. 2002;15(1): 226-52.
  20. 朴志修, 金允姬. 아토피 환자의 식이요법 및 외용요법의 조사와 체질별 적용. 대한한방소아과학회지. 2003;17(2):85-101.
  21. 장은영, 정승원, 안강모, 이상일. 소아 아토피 피부염에서의 대체보완요법 이용에 관한 연구. 천식 및 알레르기 학회지. 2005;25(2):110-6.
  22. 김창훈, 김정태, 정현아, 노석선. 아토피 피부염 환자에서 한방 추출물이 포함된 외용 제품에 대한 임상효과. 한방안이비인후피부과학회지. 2007;20(2):187-98.
  23. 황순이, 황보민, 지선영, 김소연, 권영규, 서정철. 아토피 피부염 환자에서 七葉膽을 함유한 화장품의 임상적 연구. 한방안이비인후피부과학회지. 2007;20(3):212-21.