Development and Application of High-density SNP Arrays in Genomic Studies of Domestic Animals

DOI QR코드

DOI QR Code

Fan, Bin;Du, Zhi-Qiang;Gorbach, Danielle M.;Rothschild, Max F.

  • 발행 : 2010.07.01

초록

In the past decade, there have been many advances in whole-genome sequencing in domestic animals, as well as the development of "next-generation" sequencing technologies and high-throughput genotyping platforms. Consequently, these advances have led to the creation of the high-density SNP array as a state-of-the-art tool for genetics and genomics analyses of domestic animals. The emergence and utilization of SNP arrays will have significant impacts not only on the scale, speed, and expense of SNP genotyping, but also on theoretical and applied studies of quantitative genetics, population genetics and molecular evolution. The most promising applications in agriculture could be genome-wide association studies (GWAS) and genomic selection for the improvement of economically important traits. However, some challenges still face these applications, such as incorporating linkage disequilibrium (LD) information from HapMap projects, data storage, and especially appropriate statistical analyses on the high-dimensional, structured genomics data. More efforts are still needed to make better use of the high-density SNP arrays in both academic studies and industrial applications.

키워드

Whole-genome Sequencing;HapMap;SNP Array;Genomics;Domestic Animals

참고문헌

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