Mycotoxins and Their Biotransformation in the Rumen: A Review

  • Upadhaya, Santi Devi (Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Science, College of Agriculture and Life Sciences, Seoul National University) ;
  • Park, M.A. (Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Science, College of Agriculture and Life Sciences, Seoul National University) ;
  • Ha, Jong-K. (Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Science, College of Agriculture and Life Sciences, Seoul National University)
  • Published : 2010.09.01


Mycotoxins are secondary metabolites produced by fungi. These toxins pose serious health concerns to animals as well as human beings. Biodegradation of these mycotoxins has been considered as one of the best strategies to decontaminate food and feedstuffs. Biodegradation employs the application of microbes or enzymes to contaminated food and feedstuffs. Ruminants are considered to be resistant to the adverse effects of mycotoxins presumably due to the biodegrading ability of rumen microbes compared to mono-gastric animals. Therefore, rumen microbial source or microbial enzyme could be a great asset in biological detoxification of mycotoxins. Isolation and characterization of pure culture of rumen microorganisms or isolation and cloning of genes encoding mycotoxin-degrading potential would prove to have overall beneficial impact in the food and feed industry.


  1. Abrunhosa, L. and V. Armando. 2007. Isolation and purification of an enzyme hydrolyzing ochratoxin A from Aspergillus niger. Biotechnol. Lett. 29:1909-1914.
  2. Alberts, J. F., Y. Engelbrecht, P. S. Steyn, W. H. Holzapfel and W. H. van Zyl. 2006. Biological degradation of aflatoxin B1 by Rhodococcus erythropolis cultures. Int. J. Food Microbiol. 109:121-126.
  3. Allcroft, R., B. A. Roberts and M. K. Lloyd. 1968. Excretion of aflatoxin in a lactating cow. Food Cosmet Toxicol. 6:619-625.
  4. Applegate, T. J., G. Schatzmayr, K. Prickel, C. Troche and Z. Jiang. 2009. Effect of aflatoxin culture on intestinal function and nutrient loss in laying hens. Poult. Sci. 88(6):1235-1241.
  5. Asgher, M., M. Ashraf and R. L. Legge. 2008. Recent developments in biodegradation of industrial pollutants by white rot fungi and their enzyme system. Biodegradation 19:771-783.
  6. Binder, J., E. M. Horvath, G. Schatzmayr, N. Ellend, H. Danner, R. Krska and R. Braun. 1997b. Screening for deoxynivalenol-detoxifying anaerobic rumen microorganisms. Cereal Res. Commun. 25:343-346.
  7. Binder, E. M., D. Heidler, G. Schatzmayr, N. Thimm, E. Fuchs, M. Schuh, R. Krska and J. Binder. 2000. Microbial detoxification of mycotoxins in animal feed. Proceedings of the 10th International IUPAC Symposium on Mycotoxins and Phycotoxins, Brazil.
  8. Bonsi, P., G. Augusti-Tocco, M. Palmery and M. Giorgi. 1999. Aflatoxin B1 is an inhibitor of cyclic nucleotide phosphodiesterase activity. Gen. Pharmacol. 32(5):615-619.
  9. Brown, T. 1996. Fungal diseases. In Poultry Diseases. Fourth Edition. Edited by Jordan, FTW and Paettison M. Published by W.B.Saunders limited.
  10. Butler, W. H. and G. E. Neal. 1977. Mode of action and human health aspects of aflatoxin carcinogenesis. Pure Appl. Chem. 49:1747-175.
  11. Cabassi. E., R. Di. Lecce, E. De. Angelis, A. Fusari, A. Perillo and P. Borghetti. 2004. Aflatoxicosis and vitamins A and E supplementation in sows: Immunological State of their Piglets. Vet. Res. Commun. 28:275-277.
  12. Cantley, D. C., D. A. Redmer, G. D. Osweiler and B. N. Day. 1982. Effect of zearalenone mycotoxin on luteal function in gilts. J. Anim. Sci. 55:104.
  13. Chang, K., H. J. Kurtz and C. J. Mirocha. 1979. Effects of the mycotoxin zearalenone on swine reproduction. Am. J. Vet. Res. 40:1260-1267.
  14. Choudhary, P. L., R. S. Sharma, V. N. Borkhataria and M. C. Desai. 1998. Effect of feeding aflatoxin B1 on feed consumption through naturally contaminated feeds. Ind. J. Anim. Sci. 68:400-401.
  15. Chu, F. S. 1974. Studies in ochratoxin. CRC Crit. Rev. Toxicol. 2:499.
  16. Chu, F. S., I. Noh and C. C. Chang. 1972. Structural requirements for ochratoxin intoxication. Life Sci. 11:503.
  17. Cook, W. O., J. L. Richard, G. D. Osweiller and D. W. Trampel. 1986. Clinical and pathologic changes in acute bovine aflatoxicosis: rumen motility and tissue and fluid concentrations of aflatoxins B1 and M1. Am. J. Vet. Res. 47:1817-1825.
  18. Coppock, R. W. and R. G. Christian. 2007. Aflatoxins. In: Gupta R (ed.) Veterinary Toxicology: Basic and Clinical Principles. New York: Academic Press, p. 939-950.
  19. Coulombe, R. A. Jr. 1993. Symposium: Biological action of mycotoxins. J. Dairy Sci. 76:880-891.
  20. Deiner, U. L., R. J. Col, T. H. Sander, G. A. Payne, L. S. Lee and M. A. Klich. 1987. Epidemiology of aflatoxin formation by Aspergillus flavus. Annu. Rev. Phytopathol. 25:240-270.
  21. Dicostanzo, A., L. W. H. Johnston and M. Murphy. 1996. A review of the effects of molds and mycotoxins in ruminants. Prod. Anim. Sci. 12:138-150.
  22. Diekman, M. A. and M. L. Green. 1992. Mycotoxins and reproduction in domestic livestock. J. Anim. Sci. 70:1615-1627.
  23. Dien, H. and G. Schatzmayr. 2003. Feed Mix. Vol.11, No. 1, 2003.
  24. Duncan, H. E., A. R. Ayers, G. A. Payne and W. M. Hagler Jr. 1994. Lack of fungicidal control of Aspergillus flavus in field corn. In Mycotoxins in feeds (Ed. L. W. Whitlow and W. M. Hagler Jr.). Weekly newspaper in Agribusiness. Vol 74:28. 2002.
  25. Duvick, J. 1998. Patent US 5,798,255 Pioneers Hi-Bred Int. (USA).
  26. Duvick, J., T. A. Rood, J. R. Maddox and X. Wang. 1998b. Patent US 5,792,931 Pioneer Hi-Bred Int. (USA).
  27. Dwivedi, P. and R. B. Burns. 1984. Effect of ochratoxin A on immunoglobulins in broiler chickens. Res. Vet. Sci. 36:117-121.
  28. Elling, F. and T. Moller. 1973. Mycotoxin nephropathy in pigs, Bull. World Health Org. 49: 411.
  29. Engel, V. G. and H. Hagemeister. 1978. Untersuchungenueber den verblieb von aflatoxin B1 im Verdaaundtarkt von Kuehen. In Biological Detoxification of Fungal Toxin and its use in Plant Breeding, Feed and food production. Nat.Toxins 7: 1-23. 1999.
  30. Erber, E. 1996. Patent WO 96/12414 Erber Erich KG (Austria).
  31. FAO. 2004. Electronic Forum on Biotechnology in food and agriculture. Conference11. Accessed (
  32. Fink-Gremmels, J. 2008. The role of mycotoxins in the health and performance of dairy cows. Vet. J. 176: 84-92.
  33. Fink-Gremmels, J. 2008. Mycotoxins in cattle feeds and carry-over to dairy milk: A review. Food Addit. Contam. 25(2):172-180.
  34. Fernandez, A., R. Belio, J. J. Ramos, M. C. Sanz and T. Saez. 1997. Aflatoxins and their metabolites in the tissues, faeces and urine from lambs feeding on an aflatoxin-contaminated diet. J. Sci. Food Agric. 74:161-168.<161::AID-JSFA783>3.0.CO;2-D
  35. Fernandez, A., M. Hernandez, M. T. Verde and M. Sanz. 2000. Effect of aflatoxin on performance, hematology, and clinical immunology in lambs. Can. J. Vet. Res. 64:53-58.
  36. Flowers, B., T. Cantley and B. N. Day. 1987. A comparison of the effects of zearalenone and estradiol benzoate on reproduction during the estrous cycle in gilts. J. Anim. Sci. 65:1576-1584.
  37. Foster, P. L., E. Eisenstadt and J. H. Miller. 1983. Base substitution mutations induced by metabolically activated aflatoxin B1. Proc. Natl. Acad. Sci. 80:2695-2698.
  38. Friend, D. W., B. K. Thompson, H. L. Trenholm, H. J. Boermans, K. E. Hartin and P. L. Panich. 1992. Toxicity of T-2 toxin and its interaction with deoxynivalenol when fed to young pigs. Can. J. Anim. Sci. 72:703-711.
  39. Gelderblom, W. C., K. Jaskiewicz, W. F. Marasas, P. G. Thiel, R. M. Horak, R. Vleggar and N. P. Kriek. 1988. Fumonisins novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 54:1806-1811.
  40. Gibson, R. M., C. A. Bailey, L. F. Kubena, W. E. Huff and R. B. Harvey. 1990. Impact of L-phenylalanine supplementation on the performance of three-week-old broilers fed diets containing ochratoxin, A. 1. Effects on body weight, feed conversion, relative organ weight and mortality. Poult. Sci. 69:414-419.
  41. Girish, C. K. and G. Devegowda. 2006. Efficacy of glucomannan containing yeast product (Mycosorb) and hydratedsodium calcium aluminosilicate in preventing the individual and combined toxicity of aflatoxin and T-2 toxin in commercial broilers. Asian-Aust. J. Anim. Sci. 19:877-883.
  42. Guerre, P., J. D. Bailly, G. Benard and V. Burgat. 2000. Excretion lactee des mycotoxines: quels risques peur les consommateurs.In Mycotoxins in feeds and their fate in animals: a review. Anim. Res. 51:81-99.
  43. Halasz, A., R. Latsztity, T. Abonyi and A. Bata. 2009. Decontamination of Mycotoxin-containing food and feed by biodegradation. Food Reviews International 25:284-298.
  44. Harrison, L. R., B. M. Colvin, J. T. Greene, L. E. Newman and J. R. Cole. Jr. 1990. Pulmonary edema and hydrothorax in swine produced by fumonisin FB1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest. 2:217-222.
  45. Harvey, B. B., M. H. Elissalde, L. F. Kubena, E. A. Weaver and B. A. Corrier de Clerment. 1992. Immunotoxicity of ochratoxin A to growing gilts. Am. J. Vet. Res. 53:1966-1970.
  46. Harvey, R. B., W. E. Huff, L. F. Kubena, D. E. Corrier and T. D. Phillips. 1988. Progression of aflatoxicosis in growing barrows. Am. J. Vet. Res. 49:482-487.
  47. Harvey, R. B., L. F. Kubena, D. E. Corrier, D. A. Witzel, T. D. Phillips and N. D. Heidelbaugh. 1986. Effects of deoxynivalenol in a wheat ration fed to growing lambs. Am. J. Vet. Res. 47:1631-1632.
  48. Helferich, W. G., W. N. Garrett, D. P. H. Hsieh and R. L. Baldwin. 1986. Feedlot performance and tissue residues of cattle consuming diets containing aflatoxins. J. Anim. Sci. 62:691-696.
  49. Hoerr, F. J., W. W. Carlton, B. Yagen and A. Z. Joffe. 1982. Mycotoxicosis caused by either T-2 toxin or diacetoxyscirpenol in the diet of broiler chicks. Fundam. Appl. Toxicol. 2:121-124.
  50. Huff, W. E., L. F. Kubena, R. B. Harvey and J. A. Doerr. 1988. Mycotoxin interactions in poultry and swine. J. Anim. Sci. 66:2351-2355.
  51. Huff, W. E., L. F. Kubena, R. B. Harvey and T. D. Phillips. 1992. Efficacy of hydrated sodium calcium aluminosilicate to reduce the individual and combined toxicity of aflatoxin and ochratoxin-A. Poult. Sci. 71:64-69.
  52. Hult, K., A. Teiling and S. Gatenbeck. 1976. Degradation of ochratoxin A by a ruminant. Appl. Environ. Microbiol. 32:443-444.
  53. Hult, K., E. Hokby, S. Gatenbeck and L. Rutqvist. 1980. Ochratoxin A in pig blood: Method of analysis and use as a tool for feed studies. Appl. Environ. Microbiol. 39:828-830.
  54. Humpf, H. U., E. M. Schmelz, F. I. Filmore, H. Vesper, T. R. Vales, E. Wang, D. S. Menaldino, D. C. Liotta and A. H. Merrill. Jr. 1998. Acylation of naturally occurring and syntheticl-deoxysphinganines by ceramide synthase. J. Biol. Chem. 273:19060-19064.
  55. Hussein, S. H. and M. B. Jeffrey. 2001. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167:101-134.
  56. Jones, E. R. H. and G. Lowe. 1960. The biogenesis of tricothecenes. Chem. Soc. J. 63:3959-3962.
  57. Jones, F. T., M. J. Wineland, J. T. Parsons and W. M. Hagler. 1996. Degradation of aflatoxin by poultry litter. Poult. Sci. 75:52-58.
  58. Karlovsky, P. 1999. Biological detoxification of fungal toxin and its use in plant breeding, feed and food production. Nat. Toxins 7:1-23.<1::AID-NT37>3.0.CO;2-9
  59. Kennedy, D. G., S. A. Hewitt, J. D. Mc Evoy, J. W. Currie, A. Cannavan, W. J. Blanchflower and C. T. Elliot. 1998. Zeranol is formed from Fusarium spp. toxins in cattle in vivo. Food Addit. Contam. 15(4):393-400.
  60. Kiessling, K. H., H. Pettersson, K. Sandholm and M. Olsen. 1984. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Appl. Environ. Microbiol. 47:1070-1073.
  61. Korosteleva, S. N., T. K. Smith and H. J. Boermans. 2007. Effects of feedborne Fusarium mycotoxins on the performance, metabolism, and immunity of dairy cows. J. Dairy Sci. 90:3867-3873.
  62. Krogh, P., N. H. Axelson, F. Elling, N. Gyrd-Hansen, B. Hald, J. Hyldgaard-Jensen, A. E. Larsen, A. Madsen, H. P. Mortensen, T. Moller, O. K. Petersen, U. Ravnskov, M. Rostgaard and O. Aaluund. 1974. Experimental porcine nephropathy. Changes of renal function and structure induced by ochratoxin A-contaminated feed. Acta Pathol. Microbiol. Scand. 0:1S-21S.
  63. Kuilman, M. E. M., R. F. M. Maas, D. J. Judah and J. Gremmels. 1998. Bovine hepatic metabolism of aflatoxin B1. J. Agric. Food. Chem. 46:2707-2713.
  64. Kurmanov, I. A. 1977. Fusariotoxicosis in cattle and sheep. In Mycotoxic fungi, mycotoxins and mycotoxicosis (Ed. T. D. Wyllie and L. G. Morehouse) Vol.3. Marcel Dekker, Inc., New York, NY.
  65. Kurtzman, C. P., B. W. Horn and C. W. Hesseltine. 1987. Aspergillus nomius, a new aflatoxin producing species related to Aspergillus flavus and Aspergillus tamarii. Antonie van Leeuwenhoek 53:147-158.
  66. Lillehoj, E. B. 1991. Aflatoxin: an ecologically elicited activation signal. In: Mycotoxins and Animal Foods (J. E. Smith and R. A. Anderson). CRC Press, Boca Raton, FL, pp. 119-139.
  67. Line, J. E. and R. E. Brackett. 1995. Factors affecting aflatoxin B1 removal by Flavobacterium aurantiacum. J. Food Prot. 58:91-94.
  68. Liu Yang. 2010. Effects of feed types on OTA biodegradation by Korean native goats. Masters' Thesis, Seoul National University.
  69. Liu, D. L., D. S. Yao, R. Liang, L. Ma, W. Q. Cheng and L. Q. Gu. 1998. Detoxification of aflatoxin B1 by enzymes isolated from Armillariella tabescens. Food. Chem. Toxicol. 36:563-574.
  70. Marasas, W. F. O. 1991. Toxigenic Fusaria. In: Mycotoxins and Animal Foods (Ed. J. E. Smith, and R. A. Anderson). CRC Press, Boca Raton, FL, pp. 119-139.
  71. Marquardt, R. R. 1996. Effects of molds and their toxins on livestock performance: a western Canadian perspective. Anim. Feed Sci. Technol. 58:77-89.
  72. Michael, H. H. 2006. Mycotoxin In feeds: CVM'S Perspective, FDA US. Accessed (
  73. Mobashar, M., J. Hummel, R. Blank and K. H. Sudekum. 2010. Ochratoxin A in ruminants - A Review on its degradation by Gut Microbes and effects on animals. Toxins 2:809-839.
  74. Moss, M.O. 1996. Mycotoxic fungi. In: Microbial Food Poisoning. Second edition (Ed. A. R. Eley). Published by Chapman and Hall.
  75. Muller, G., P. Kielstein, H. Rosner, A. Berndt, M. Heller and H. Kohler. 1999. Studies of the influence of ochratoxin A on immune and defense reactions in weaners. Mycoses 42:495-505.
  76. Nam, I. S., P. C. Garnsworthy and J. H. Ahn. 2009. Effects of freeze dried citrus peel on feed preservation, aflatoxin contamination and in vitro ruminal fermentation. Asian-Aust. J. Anim Sci. 22:674-680.
  77. Neal, G. E., D. J. Judah, P. Carthew, A. Verma, I. Latour, L. Weir, R. D. Coker, M. J. Nagler and L. A. Hoogenboom. 2001. Differences detected in vivo between samples of aflatoxin contaminated peanut meal, following decontamination by two ammonia based processes. Food Addit. Contam. 18(2):137-149.
  78. Nibbelink, S. K. 1986. Aflatoxicosis in food animals: A clinical review. Iowa State Univ. Vet. 48:28-31.
  79. Ortatatli, M., H. Oguz, F. Hatipoglu and M. Karaman. 2005. Evaluation of pathological changes in broilers during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure. Res. Vet. Sci. 78:61-68.
  80. Patterson, D. S. P., B. J. Shreeve, A. B. Roberts, P. J. Brush and E. M. Glancy. 1981. Effect on calves of barley naturally contaminated with ochratoxin A and groundnut meal contaminated by low concentration of aflatoxin B1. Res. Vet. Sci. 31:213-218.
  81. Petchkongkaew, A., P. Taillandier, P. Gasaluck and A. Lebrihi. 2008. Isolation of Bacillus spp. from Thai fermented soybean (Thua-nao): screening for aflatoxin B1 and ochratoxin A detoxification. J. Appl. Microbiol. 104:1495-1502.
  82. Peteri, Z., J. Terenb, C. Vagvo lgyia and J. Varga. 2007. Ochratoxin degradation and adsorption caused by astaxanthin-producing yeasts. Food Microbiol. 24:205-221.
  83. Pfohl-Leszkowicz, A. 2000. Risques mycotoxicologiques pour la sante des animaux et de I'homme, Cah. In Mycotoxins in feeds and their fate in animals: a review. Anim. Res. 51:81-99.
  84. Phillips, T. D. 1999. Dietary clay in the chemoprevention of aflatoxin induced disease. Toxicol. Sci. 52:118-126.
  85. Pitout, M. J. 1969. The hydrolysis of ochratoxin A by some proteolytic enzymes. Biochem. Pharmacol. 18(2):485-491.
  86. Politis, I., K. Fegeros, G. Schatzmayr and D. Kantas. 2005. Use of Trichosporon mycotoxinivorans to suppress the effects of ochratoxicosis on the immune system of broiler chicks. Br. Poult. Sci. 46(1):58-65.
  87. Pompa, G., C. Montesissa, F. M. Di Lauroa and L. Fadini. 1986. The metabolism of zearalenone in subcellular fractions from rabbit and hen hepatocytes and its estrogenic activity in rabbits. Toxicology 42(1):69-75.
  88. Raju, M. V. L. N. and G. Devegowda. 2000. In Mycotoxins: Their effects in poultry and some practical solutions. 2005. The Mycotoxin Blue Book (Ed. D. E. Diaz). Nottingham University Press.
  89. Ramos, A. J. and E. Hernandez. 1996. In vitro aflatoxin adsorption by means of a montmorillonite silicate. A study of adsorption isotherms. Anim. Feed Sci. Technol. 62:263-269.
  90. Ribelin, W. E., K. Fukushima and P. E. Still. 1978. The toxicity of ochratoxin A to ruminants. Can. J. Comp. Med. 42:172-176.
  91. Riley, R. T. 1998. Mechanistic interactions of mycotoxins: theoretical considerations. In Mycotoxins in Agriculture and Food Safety (Ed. K. K. Sinha and D. Bhatnagar) Marcel Dekker Inc., New York, 227-253.
  92. Santin, E., A. Maiorka, E. L. Krabbe, A. C. Paulillo and A. C. Alessi. 2002. Effect of hydrated sodium calcium aluminosilicate on the prevention of the toxic effects of ochratoxin. J. Appl. Poult. Res. 11:22-28.
  93. Schatzmayr, G., D. Heidler, E. Fuchs, A.P. Loibner, R. Braun and E. M. Binder. 2002. Evidence of ochratoxin A-detoxification activity of rumen fluid, intestinal fluid and soil samples as well as isolation of relevant microorganisms from these environments. Mycotoxin Res. 18A:183-187.
  94. Schatzmayr, G., F. Zehner, M. Taubel, D. Schatzmayr, A. Klimitsch, A. P. Loibner and E. M. Binder. 2006. Microbiologicals for deactivating mycotoxins. Mol. Nutr. Food Res. 50:543-551.
  95. Seeling, K., S. Danicke, H. Valenta, H. P. van Egmond, R. C. Schothorst, A. A. Jekel, P. Lebzein, M. Schollenberger, E. Razzazi-fazeli and G. Flachowsky. 2006. Effects of Fusarium toxin contaminated wheat and feed intake level on biotransformation and carry-over of deoxynivalenol in dairy cows. Food Addit. Contam. 23(10):1008-1020.
  96. Shapira, R. 2004. Detection and control. In Qinghua Wu, Alena Jezkova, Zonghui Yuan, Lucie Pavlikova, Vlastimil Dohna,and Kamil Biological degradation of aflatoxins. Drug Metab. Rev. 41(1):1-7.
  97. Sharma, R. P. 1993. Immunotoxicity of mycotoxins. J. Dairy Sci. 76:892-897.
  98. Shen, H. M., C. Y. Shi, H. P. Lee and C. N. Ong. 1994. Aflatoxin B1-induced lipid peroxidation in rat liver. Toxicol. Appl. Pharmacol. 127(1):145-150.
  99. Shi, Y. H., Z. R. Zu, J. L. Feng, M. S. Xia and C. H. Hu. 2005. Effects of modified montmorillonite nanocomposite on growing/finishing pigs during aflatoxicosis. Asian-Aust. J. Anim. Sci. 18:1305-1309.
  100. Shreeve, B. J., D. S. P. Patterson, G. A. Pepin, B. A. Roberts and A. E. Wzathall. 1977. Effect of feeding ochratoxin to pigs during early pregnancy. Br. Vet. J. 133:412-417.
  101. Singh, G. S., H. V. Chauhan, G. J. Jha and K. K. Singh. 1990. Immunosuppression due to chronic ochratoxicosis in broiler chicks. Pathology 103:399-410.
  102. Southern, L. L. and A. J. Clawson. 1979. Effects of aflatoxins on finishing swine. J. Anim. Sci. 49:1006-1011.
  103. Sreemannarayana, O., A. A. Frohlich, T. G. Vitti, R. R. Marquardt and D. Abramson. 1988. Studies of tolerance and disposition of ochratoxin A in young calves. J. Anim. Sci. 66:1703-1711.
  104. Stefan, H., D. Hartingerb, M. Thamhesl, E. Vekiru, R. Krska, G. Schatzmayr, W. D. Moll and R. Grabherr. 2010. Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes. J. Biotechnol. 145:120-129.
  105. Stoev, S. D., D. Goundasheva, T. Mirtcheva and P. Mantle. 2000. Susceptibility to bacterial infections in growing pigs as an early response in ochratoxicosis. Exp. Toxicol. Pathol. 52:287-296.
  106. Stoev, S. D., S. Vitanov, G. Anguelov, T. Petkova Bocharova and E. E. Creppy. 2001. Experimental porcine nephropathy in pigs provoked by a diet containing ochratoxin A and Penicillic acid, Vet. Res. Commun. 25:205-223.
  107. Swanson, S. P., J. Nicoletti, H. D. Rood, W. Buck and L. M. Cote. 1987. Metabolism of three trichothecene mycotoxins, T-2 toxin, diacetoxyscirpenol, and deoxynivalenol, by bovine rumen microorganisms. J. Chromatogr. 414: 335-342.
  108. Takayama, H., N. Shimada, O. Mikami and H. Murata. 2005. Suppressive effect of deoxynivalenol, Fusarium mycotoxin, on bovine and porcine neutrophil chemiluminescence: an in vitro study. J. Vet. Med. Sci. 67(5):531-5333.
  109. Tiemann, U. and S. Danicke. 2007. In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: A review. Food Addit. Contam. 24(3):306-314.
  110. Tiemann, U., K. P. Brussow, U. Kuchenmeister, L. Jonas, R. Pohland, A. Reischauer, K. Jager and S. Danicke. 2008. Changes in the spleen and liver of pregnant sows and full-term piglets after feeding diets naturally contaminated with deoxynivalenol and zearalenone. Vet. J. 176:188-196.
  111. Towers, N. R. and J. M. Sposen. 1993. Zearalenone-induced infertility in sheep and cattle in New Zealand. N.Z. Vet. J. 41:223-224.
  112. Towner, R. A., H. Hashimoto and P. M. Summers. 2000. Non-invasive in vivo magnetic resonance imaging assessment of acute aflatoxin B1 hepato-toxicity in rats. Biochem. Biophys. Acta 1475:314-320.
  113. Upadhaya, S. D., H. G. Sung, C. H. Lee, S. Y. Lee, S. W. Kim, K. J. Jo and J. K. Ha. 2009. Comparative study on the aflatoxin B1 degradation ability of rumen fluid from Holstein steers and Korean native goats. J. Vet. Sci. 10(1):29-34.
  114. Van Heugten, E., J. W. Spears, M. T. Coffey, E. B. Kegley and M. A. Qureshi. 1994. The effect of methionine and aflatoxin on immune function in weanling pigs. J. Anim. Sci. 72:658-664.
  115. Vasanthi, S. and R. V. Bhat. 1998. Mycotoxins in foods-occurrence, health & economic significance and food control measures. Ind. J. Med. Res. 108:212-224.
  116. Verma, D. 2007. New facts about mycotoxin control-intensive research in the field of mycotoxin deactivation gives new insights! Biomin India.
  117. Wang, R. J., S. X. Fui, C. H. Miao and D. Y. Feng. 2006. Effects of different mycotoxin adsorbents on performance, meat characteristics and blood profiles of avian broilersfed mold contaminated corn. Asian-Aust. J. Anim. Sci. 19:72-79.
  118. Watson, S. A., C. J. Mirocha and A. W. Hayes. 1984. Analysis for tricothecenes in samples from Southeast Asia associated with "yellow rain". Fundam. Appl. Toxicol. 4:700-717.
  119. Westlake, K., R. I. Mackie and M. F. Dutton. 1989. In vitro metabolism of mycotoxins by bacterial, protozoal and ovine ruminal fluid preparations. Anim. Feed Sci. Technol. 25:169-178.
  120. Wu, J., D. Miller and E. A. Casman. 2004. Bt maize and mycotoxin reduction: economic impacts in the United States and the developing world. J. Toxicol. Toxin Rev. 23:397-424.
  121. Xiao, H., R. R. Marquardt, A. A. Frohlich, G. D. Phillips and T. G. Vitti. 1991. Effect of a hay and a grain diet on the bioavailability of ochratoxin A in the rumen of sheep. J. Anim. Sci. 69(9):3715-3723.
  122. Yiannikouris, A. and J. P. Jouany. 2002. Mycotoxins in feeds and their fate in animals: a review. Anim. Res. 51:81-99.
  123. Zwierzchowski, W., M. Przybyłowicz, K. Obremski, L. Zielonka, E. Skorska-WyszyNska, M. Gajecka, M. Polak, E. Jakimiuk, B. Jana, L. Rybarczyk and M. Gajecki. 2005. Level of zearalenone in blood serum and lesions in ovarian follicles of sexually immature gilts in the course of zearalenone mycotoxicosis. Pol J. Vet. Sci. 8(3):209-218.

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