Effect of Anti-atopic Allergic Reaction in Response to Oriental Herb Extracts

생약재 추출물의 아토피 완화효과

  • Yang, Hee-Jin (Department of Food Science and Biotechnology, Sungkyunkwan University) ;
  • Park, Kye-Won (Department of Food Science and Biotechnology, Sungkyunkwan University) ;
  • Kim, Hyun-Suck (Sungkyun Biotech, Co., Ltd.) ;
  • Cho, Soo-Muk (Department of agro-Food Resources, National Academy of Agricultural Science) ;
  • Park, Ki-Moon (Department of Food Science and Biotechnology, Sungkyunkwan University)
  • 양희진 (성균관대학교 식품생명공학과) ;
  • 박계원 (성균관대학교 식품생명공학과) ;
  • 김현석 ((주)성균바이오텍) ;
  • 조수묵 (국립농업과학원 기능성식품과) ;
  • 박기문 (성균관대학교 식품생명공학과)
  • Received : 2009.10.20
  • Accepted : 2009.11.04
  • Published : 2010.02.28

Abstract

The in vivo and in vitro effects of oriental herb extracts of Cassia obtusifolia, Taraxacum platycarpum and Ulmusmacrocarpa on anti-atopic allergic reaction were evaluated in this study. A mixture of these extracts exhibited more potent anti-allergic activities in human mast cells than those from individual extracts. The herbal mixture significantly inhibited the release of compound 48/80-induced $\beta$-hexosaminidase release in the human mast cell line, HMC-1. The mixture also suppressed the production of PMA and A23187-induced inflammatory cytokines in HMC-1 cells. To further investigate the in vivo effects of the herbal mixture, a Dermatophagoides farinae (DF)-induced atopic dermatitis mouse model was utilized. Oral administration of the herbal mixture significantly decreased the ear thickness and swelling in DF treated NC/Nga mice in a dose dependent manner. Furthermore, serum levels of IgE and interleukin-4 (IL-4) were significantly decreased, whereas interferon-gamma (IFN-$\gamma$) levels were increased in the mixture administrated groups when compared to the control. Taken together, our data indicate the possibility of using a mixture of the oriental herb extract to relieve symptoms of atopic dermatitis.

Keywords

Cassia obtusifolia;Taraxacum platycarpum;Ulmus macrocarpa;anti-atopic allergic reaction

Acknowledgement

Supported by : 농촌진흥청

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