Analytical trend of perfluorinated compounds in environmental and biota samples

환경 및 생체시료 중 과불화 화합물의 분석 동향

  • Received : 2010.04.16
  • Accepted : 2010.07.04
  • Published : 2010.08.25


Perfluorinated compounds have characteristics of resistance to heat, acidic, basic conditions and also resist water, oil, grease, pollutant. Futhermore they are used by various industrial material, nowadays, they produced in large scale for indutrial and commercial areas. However, they also resist metabolizing and degrading in environmental system (plant, animal, even human body). Moreover, in animal's bodies, PFCs can be accumulated in organ (eg; liver) and lead to liver cell necrosis even oncogenesis. Perfluorinated compounds are newly registered as new persistent organic pollutants (POPs) on Stockholm convention in 2009. Therefore necessity for analytical methodology for determination of PFCs in various environmental samples is even more increased. This study discussed sample preparation and instrumental conditions for the analysis of PFCs in environmental and biota samples.


perfluorinated compounds;sediments;sludge;blood;plasma;serum;LC-MS;LC-MS/MS


  1. B. D. Key, R. D. Howell and C. S. Criddle, Environ. Sci. Technol., 31, 2445(1997).
  2. R. Renner, Environ. Sci. Technol., 35, 154A(2001).
  3. L. Cui, Q. Zhou, C. Liao, J. Fu and G. Jiang, Arch. Environ. Contam. Toxicol., 56, 338(2009).
  4. J. L. Newsted, S. A. Beach, S. P. Gallagher and J. P. Giesy, Arch. Environ. Contam. Toxicol., 50, 411(2006).
  5. C. Lau, K. Anitole, C. Hodes, D. Lai, A. Pfahles-Hutchens and J. Seed, Toxicol. Sci., 99(2), 366(2007).
  6. Stockholm convention, Perfluorooctane sulfonic acid (PFOS), its salts and perfluorooctane sulfonyl fluoride (PFOS-F), decision SC-4/17, Annex B, Stockholm convention, Geneva, Switzerland, 2009
  7. US EPA, Perfluorooctyl sulfonates. Proposed significant new use rule, 40 CFR Part 721, US EPA, Washington DC, 2002.
  8. OECD, Co-operation on existing chemicals-Hazard assessment of perfluorooctane sulfonate and its salts. Environment Directorate Joint Meeting of the Chemicals Committe and the Working Party on Chemicals, Pesticides and Biotechnology, Organisation for Economic Co-operation and Development, Paris, 2002.
  9. EU, Directive 2006/122/ECOF, the European Parliament and of the Council, Off. J. Eur. Union, L372, 32(2006).
  10. E. Kissa, Fluorinated surfactants: synthesis, properties, applications. Marcel Dekker, New York, 1994.
  11. 3M, Sulfonated perfluorochemicals in the environment: Sources, dispersion, fate and effects. 3M, St. Paul, MN, 2000.
  12. C. A. Moody and J. A. Field, Environ. Sci. Technol., 33, 2800(1999).
  13. C. A. Moody, W. C. Kwan, J. W. Martin, D. C. G. Muir and S. A. Mabury, Anal. Chem., 73, 2200(2001).
  14. C. A. Moody, J. W. Martin, W. C. Kwan, D. C. G. Muir and S. A. Mabury, Environ. Sci. Technol., 36, 545(2002).
  15. H. F. Schrder, J. Chromatogr. A, 1020, 131(2003).
  16. M. M. Schultz, D. F. Barofsky and J. A. Field, Environ. Eng. Sci., 20, 487(2003).
  17. E. Kissa, Fluorinated surfactants and repellents. Marcel Dekker, New York, 1994.
  18. G. T. Tomy, S. A. Tittlemier, V. P. Palace, W. R. Budakowski, E. Braekevelt, L. Brinkworth and K. Friesen, Environ. Sci. Technol., 38, 758(2004).
  19. S. Taniyasu, K. Kannan, U. Horii, N. Hanari and N. Yamashita, Environ. Sci. Technol., 37, 2634(2003).
  20. S. Taniyasu, K. Kannan, M. K. So, A. Gulkowska, E. Sinclair, T. Okazawa and N. Yamashita, J. Chromatogr. A, 1093, 89(2005).
  21. M. Villagrasa, M. L. Alba and D. Barcel, Anal. Bioanal. Chem., 386, 953(2006).
  22. H. Lehmler, Chemosphere, 58, 1471(2005).
  23. M. J. A. Dinglasan, Y. Ye, E. A. Edwards and S. A. Mabury, Environ. Sci. Technol., 38, 2857(2004).
  24. N. L. Stock, F. K. Lau, D. A. Ellis, J. W. Martin, D. C. G. Muir and S. A. Mabury, Environ. Sci. Technol., 38, 991(2004).
  25. D. F. Hagen, J. Belisle, J. D. Johnson and P. Venkateswarlu, Anal. Biochem., 118, 336(1981).
  26. A. Krrman, B. Bavel, U. Jrnberg, L. Hardell and G. Lindstrm, Anal. Chem., 77, 864(2005).
  27. N. Yamashita, K. Kannan, S. Taniyasu, Y. Horii, T. Okazawa, G. Petrick and T. Gamo, Environ. Sci. Technol., 38, 5522(2004).
  28. K. Inoue, F. Okada, R. Ito, S. Kato, S. Sasaki, S. Nakajima, A. Uno, Y. Saijo, F. Sata, Y. Yoshimura, R. Kishi and H. Nakazawa, Environ. Health. Perspect., 112, 1204(2004).
  29. R. G. Luthy, G. R. Alken, M. L. Brusseau, S. D. Cunningham, P. M. Gschwend, J. J. Pignatello, M. Reinhard, S. J. Traina, Jr. W. J. Wever and J. C. Westall, Environ. Sci. Technol., 31, 3341(1997).
  30. J. C. Westall, H. Chen, W. Zhang, and B. J. Brownawell, Environ. Sci. Technol., 33, 3110(1999).
  31. C. P. Higgins, J. A. Field, C. S. Criddle and R. G. Luthy, Environ. Sci. Technol., 39, 3946(2005).
  32. P. D. Jones, W. Hu, W. Coen, J. L. Newsted and J. P. Giesy, Environ. Toxicol. Chem., 22, 2639(2003).
  33. A. Holm, S. T. Wilson, P. Molander, E. Lundanes and T. Greibrokk, J. Sep. Sci., 27, 1071(2004).
  34. Z. Kuklenyik, J. A. Reich, J. S. Tully, L. L. Needhan and A. M. Calafat, Environ. Sci. Technol., 38, 3698(2004).
  35. J. Belisle and D. F. Hagen, Anal. Biochem., 101, 369(1980).
  36. K. Inoue, F. Okada, R. Ito, M. Kawaguchi, N. Okanouchi and H. Nakazawa, J. Chromatogr. B, 810, 49(2004).
  37. K. Kannan, K. J. hansen, T. L. Wade and J. P. Giesy, Arch. Environ. Contam. Toxicol., 42, 313(2002).
  38. K. Kannan, J. C. Franson, W. W. Bowerman, K. J. Hansen, P. D. Jones and J. P. Giesy, Environ. Sci. Technol., 35, 3065(2001).
  39. K. Kannan, J. Koistinen, K. Beckmen, T. Evans, J. F. Gorzelany, K. J. Hansen, P. D. Jones, E. Helle, M. Nyman and J. P. Giesy, Environ. Sci. Technol., 35, 1593(2001).
  40. K. Kannan, J. W. Choi, N. Iseki, K. Senthilkumar, D. H. Kim, S. Masunaga and J. P. Giesy, Chemosphere, 49, 225(2002).
  41. G. W. Olsen, T. R. Church, E. B. Larson, G. Belle, J. K. Lundberg, K. J. Hansen, J. M. Burris, J. H. Mandeland L. R. Zobel, Chemosphere, 54, 1599(2004).
  42. K. J. Hansen, L. A. Clemen, M. E. Ellefson and H. O. Johnson, Environ. Sci. Technol., 35, 766(2001).
  43. US EPA, Perfluorooctane sulfonate: Current summary of human sera, health and toxicology data (Doc: AR226-0048). US EPA, Washington DC, 1999.
  44. G. W. Olsen, K. J. Hansen, L. A. Stevenson, J. M. Burris and J. H. Mandel, Environ. Sci. Technol., 37, 888(2003).
  45. US EPA, Draft of hazard assessment of perfluorooctanoic acid and its salts (Doc: AR226-1079). US EPA, Washington DC, 2002.
  46. J. P. Giesy and K. Kannan, Environ. Sci. Technol., 35, 1339(2001).
  47. K. Kannan, J. Newsted, R. S. Halbrook and J. P. Giesy, Environ. Sci. Technol., 36, 2566(2002).
  48. P. de Voogt and M. Sez, Trends. Anal. Chem., 25, 326(2006).
  49. J. W. Martin, D. C. G. Muir, C. A. Moody, D. A. Ellis, W. C. Kwan, K. R. Solomon and S. A. Mabury, Anal. Chem., 74, 584(2002).
  50. G. Yamamoto, K. Yoshitake, T. Sato, T. Kimura and T. Ando, Anal. Biochem., 182, 371(1989).
  51. C. A. Moody and J. A. Field, Environ. Sci. Technol., 34, 3864(2000).
  52. M. Hudlicky and A. E. Pavlath, Chemistry of organic fluorine compounds II: A critical review. American Chemical Society, Washington DC, 1995.
  53. J. March, Advanced organic chemistry, 3rd edn. Wiley, New York, 1985.
  54. D. W. Kuehl and B. Rozynov, Rapid. Commun. Mass. Spectrom., 17, 2364(2003).
  55. K. J. Hansen, H. O. Johnson, J. S. Eldridge, J. L. Butenhoff and L. A. Dick, Environ. Sci. Technol., 36, 1681 (2002).
  56. I. Langlois and M. Oehme, Organohalogen Compd., 66, 3973(2004).
  57. G. Lindstrm, A. Krrman and B. Bavel, J. Chromatogr. A, 1216, 394(2009).
  58. M. M. Schultz, D. F. Barofsky and J. A. Field, Environ. Sci. Technol., 40, 289(2006).
  59. N. Riddell, G. Arsenault, J. P., Benskin, B, Chittim, J. W. Martin, A. McAlees and R. McCrindle, Environ. Sci. Technol., 43, 7902(2009).
  60. B. Boulanger, J. Vargo, J. L. Schnoor and K. C. Hornbuckle, Environ. Sci. Technol., 38, 4064(2004).
  61. C. Sottani and C. Minoia, Rapid. Commun. Mass. Spectrom., 16, 650(2002).
  62. M. Takino, S. Daishima and T. Nakahara, Rapid. Commun. Mass. Spectrom., 17, 383(2003).
  63. E. Chan, M. Sandhu, J. P. Benskin, M. Ralitsch, N. Thibault, D. Birkholz and J. W. Martin, Rapid. Commun. Mass. Spectrom., 23, 1405(2009).

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