A case of treatment on amitraz toxicosis in a Thoroughbred racehorse

Thoroughbred 경주마에서 amitraz 중독증 치료 1례

  • Yang, Jaehyuk (Equine Hospital of Busan Race Park, Korea Racing Authority) ;
  • Song, Heeeun (Equine Hospital of Busan Race Park, Korea Racing Authority) ;
  • Lee, Kyuong-Kap (College of Veterinary Medicine, Jeju National University) ;
  • Jee, Youngheun (College of Veterinary Medicine, Jeju National University) ;
  • Woo, Ho-Choon (College of Veterinary Medicine, Jeju National University) ;
  • Lim, Yoon-Kyu (College of Veterinary Medicine, Jeju National University)
  • 양재혁 (한국마사회 부산경남경마공원) ;
  • 송희은 (한국마사회 부산경남경마공원) ;
  • 이경갑 (제주대학교 수의과대학) ;
  • 지영흔 (제주대학교 수의과대학) ;
  • 우호춘 (제주대학교 수의과대학) ;
  • 임윤규 (제주대학교 수의과대학)
  • Accepted : 2010.08.18
  • Published : 2010.09.30

Abstract

A 3-year-old female Thoroughbred racehorse was presented following the accidental oral and skin administration of amitraz. This case report describes the clinical signs and the treatment of this horse. Clinical signs of amitraz toxicosis are associated with the stimulation of alpha2-adrenergic receptors. Amitraz is seldom fatal because the effects can be reversed by alpha2-adrenergic antagonists. The horse displayed typical clinical signs of colic, including pawing, small hard drops, tranquillisation, depression, ataxia, muscular incoordination and impaction colic lasting up to 7 days. The syndrome was accompanied by mild dehydration. The horse survived after persistent symptomatic treatment, including the giving of intravenous fluids, antibiotics, multiple doses of mineral oil per os, nonsteroidal anti-inflammatory drugs and dexamethasone intramuscularly and intravenously.

References

  1. 신진영, 오기석, 신동호, 김성호, 김형진, 박승춘, 이현숙, 정문구, 김종춘. 임신 중 살충제 amitraz에 노출된 랫드의 모독성 평가. 대한수의학회지 2004, 44, 523-532.
  2. 윤형준, 윤소미, 이명헌, 손성완. HPLC-PDA를 이용한 Amitraz의 분석법 확립 및 검증. 대한수의학회지 2008, 48, 33-38.
  3. 이상은, 김덕환. German Shepherd의 프리벤틱 중독 3례. 한국임상수의학회지 2007, 24, 264-268.
  4. Atabek ME, Aydin K, Erkul I. Different clinical features of amitraz poisoning in children. Hum Exp Toxicol 2002, 21, 13-16. https://doi.org/10.1191/0960327102ht207oa
  5. Auer DE, Seawright AA, Pollitt CC, Williams G. Illness in horses following spraying with amitraz. Aust Vet J 1984, 61, 257-259. https://doi.org/10.1111/j.1751-0813.1984.tb15536.x
  6. Avsarogullari L, Ikizceli I, Sungur M, Sozuer E, Akdur O, Yucei M. Acute amitraz poisoning in adults: clinical features, laboratory findings, and management. Clin Toxicol (Phila) 2006, 44, 19-23. https://doi.org/10.1080/15563650500357545
  7. Aydin K, Kurto lu S, Poyrazo lu MH, Uzüm K, Ustunbas HB, Hallac IK. Amitraz poisoning in children: clinical and laboratory findings of eight cases. Hum Exp Toxicol 1997, 16, 680-682. https://doi.org/10.1177/096032719701601109
  8. Aziz SA, Knowles CO. Inhibition of monoamine oxidase by the pesticide chlordimeform and related compounds. Nature 1973, 242, 417-418. https://doi.org/10.1038/242417a0
  9. Bonsall JL, Turnbull GJ. Extrapolation from safety data to management of poisoning with reference to amitraz (a formamidine pesticide) and xylene. Human Toxicol 1983, 2, 587-592. https://doi.org/10.1177/096032718300200403
  10. Bowman DD, Lynn RC, Eberhard ML, Alcaraz A. Georgis' Parasitology for Veterinarians. 8th ed. pp. 44- 253, Saunders, St. Louis, 2003.
  11. Caksen H, Odaba D, Arslan S, Akgun C, Ata B, Akbayram S, Tuncer O. Report of eight children with amitraz intoxication. Hum Exp Toxicol 2003, 22, 95-97. https://doi.org/10.1191/0960327103ht333sr
  12. Demirel Y, Yilmaz A, Gursoy S, Kaygusuz K, Mimaroglu C. Acute amitraz intoxication: retrospective analysis of 45 cases. Hum Exp Toxicol 2006, 25, 613-617. https://doi.org/10.1177/096032706072472
  13. Doganay Z, Aygun D, Altintop L, Guven H, Bildik F. Basic toxicological approach has been effective in two poisoned patients with amitraz ingestion: case reports. Hum Exp Toxicol 2002, 21, 55-57. https://doi.org/10.1191/0960327102ht204cr
  14. Ertekin V, Alp H, Selimo lu MA, Karacan M. Amitraz poisoning in children: retrospective analysis of 21 cases. J Int Med Res 2002, 30, 203-205. https://doi.org/10.1177/147323000203000215
  15. Grossman MR. Amitraz toxicosis associated with ingestion of an acaricide collar in a dog. J Am Vet Med Assoc 1993, 203, 55-57.
  16. Harkins JD, Queiroz-Neto A, Mundy GD, West D, Tobin T. Development and characterization of an equine behaviour chamber and the effects of amitraz and detomidine on spontaneous locomotor activity. J Vet Pharmacol Ther 1997, 20, 396-401. https://doi.org/10.1046/j.1365-2885.1997.00089.x
  17. Jorens PG, Zandijk E, Belmans L, Schepens PJ, Bossaert LL. An unusual poisoning with the unusual pesticide amitraz. Hum Exp Toxicol 1997, 16, 600-601. https://doi.org/10.1177/096032719701601008
  18. Kalyoncu M, Dilber E, Okten A. Amitraz intoxication in children in the rural Black Sea region: analysis of forty-three patients. Hum Exp Toxicol 2002, 21, 269-272. https://doi.org/10.1191/0960327102ht241oa
  19. Kennel O, Prince C, Garnier R. Four cases of amitraz poisoning in humans. Vet Hum Toxicol 1996, 38, 28-30.
  20. Mair TS, Divers TJ, Ducharme NG. Manual of Equine Gastroenterology. 1st ed. pp. 119-125, Saunders, London, 2002.
  21. Orsini JA, Divers TJ. Equine Emergencies: Treatment and Procedures. 3rd ed. pp. 593-596, Saunders, St. Louis, 2008.
  22. Osano O, Oladimeji AA, Kraak MH, Admiraal W. Teratogenic effects of amitraz, 2,4-dimethylaniline, and paraquat on developing frog (Xenopus) embryos. Arch Environ Contam Toxicol 2002, 43, 42-49. https://doi.org/10.1007/s00244-002-1132-4
  23. Osweiler GD. Toxicology. 1st ed. pp. 245-246, Williams & Wilkins, Philadelphia, 1996.
  24. Papich MG. Saunders Handbook of Veterinary Drugs. 2nd ed. pp. 23-24, Saunders, St. Louis, 2007.
  25. Pass MA, Mogg TD. Pharmacokinetics and metabolism of amitraz in ponies and sheep. J Vet Pharmacol Ther 1995, 18, 210-215. https://doi.org/10.1111/j.1365-2885.1995.tb00580.x
  26. Reed SM, Bayly WM, Sellon DC. Equine Internal Medicine. 2nd ed. pp. 929-930, Saunders, St. Louis, 2004.
  27. Roberts MC, Argenzio A. Effects of amitraz, several opiate derivatives and anticholinergic agents on intestinal transit in ponies. Equine Vet J 1986, 18, 256-260. https://doi.org/10.1111/j.2042-3306.1986.tb03620.x
  28. Sellers AF, Lowe JE, Drost CJ, Rendano VT, Georgi JR, Roberts MC. Retropulsion-propulsion in equine large colon. Am J Vet Res 1982, 43, 390-396.
  29. Ulukaya S, Demirag K, Moral AR. Acute amitraz intoxication in human. Intensive Care Med 2001, 27, 930-933. https://doi.org/10.1007/s001340100934
  30. Webster CRL. Clinical Pharmacology. 1st ed. pp. 68- 93, Teton NewMedia, Wyoming, 2001.
  31. White NA. The Equine Acute Abdomen. 1st ed. pp. 53-377, Lea & Febiger, Philadelphia, 1990.
  32. Yaramis A, Soker M, Bilici M. Amitraz poisoning in children. Hum Exp Toxicol 2000, 19, 431-433. https://doi.org/10.1191/096032700682694215
  33. Yilmaz HL, Yildizdas DR. Amitraz poisoning, an emerging problem: epidemiology, clinical features, management, and preventive strategies. Arch Dis Child 2003, 88, 130-134. https://doi.org/10.1136/adc.88.2.130