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A Statistical Approach to the Pharmacokinetic Model

집단 약동학 모형에 대한 통계학적 고찰

Lee, Eun-Kyung
이은경

  • Received : 20100200
  • Accepted : 20100400
  • Published : 2010.06.30

Abstract

The Pharmacokinetic model is a complex nonlinear model with pharmacokinetic parameters that is some-times represented by a complex form of differential equations. A population pharmacokinetic model adds individual variability using the random effects to the pharmacokinetic model. It amounts to the nonlinear mixed effect model. This paper, reviews the population pharmacokinetic model from a statistical viewpoint; in addition, a population pharmacokinetic model is also applied to the real clinical data along with a review of the statistical meaning of this model.

Keywords

Population pharmacokinetics;mixed effect model;nonlinear function

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Cited by

  1. Estimation Methods for Population Pharmacokinetic Models using Stochastic Sampling Approach vol.28, pp.2, 2015, https://doi.org/10.5351/KJAS.2015.28.2.175

Acknowledgement

Supported by : 한국학술진흥재단