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Predicting Survival of DLBCL Patients in Pathway-Based Microarray Analysis

DLBCL 환자의 대사경로 정보를 이용한 생존예측

Lee, Kwang-Hyun;Lee, Sun-Ho
이광현;이선호

  • Received : 20100400
  • Accepted : 20100500
  • Published : 2010.08.31

Abstract

Predicting survival from microarray data is not easy due to the problem of high dimensionality of data and the existence of censored observations. Also the limitation of individual gene analysis causes the shift of focus to the level of gene sets with functionally related genes. For developing a survival prediction model based on pathway information, the methods for selecting a supergene using principal component analysis and testing its significance for each pathway are discussed. Besides, the performance of gene filtering is compared.

Keywords

Microarray experiment;survival analysis;pathway;principal component analysis;proportional hazards model

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Acknowledgement

Supported by : 한국학술진흥재단