- Volume 10 Issue 10
DOI QR Code
Electrophysiological Features of Diabetic Polyneuropathy: Motor Nerve Conduction Studies
당뇨병성다발신경병증의 전기생리학적 특징: 운동신경전도검사
- Received : 2010.08.23
- Accepted : 2010.10.06
- Published : 2010.10.28
Nerve conduction studies (NCS) are the most objective measure of nerve function and essential for the diagnosis of sub-clinical neuropathy in diabetes mellitus and diabetic polyneuropathy (DPN). This study evaluates the characteristic of electrophysiological abnormalities in DPN. Electrodiagnostic data from 120 patients with diabetic polyneuropathies and 77 control subjects were reviewed. Motor nerve conduction velocities (MNCV), distal motor latencies (DML), compound muscle action potential (CMAP) amplitudes, No potential frequency and conduction block were analyzed. Data were normalized based on normative reference values, and the proportion of nerves with abnormal values in the lower and upper limbs were evaluated. DPN was systemic demyelinating peripheral polyneuropathy and more severe abnormal nerve conduction was found in lower limbs than in upper limbs. The abnormal degree was more severe in peroneal nerve. It was no statistically significant difference of conduction block in control and DPN group. Our findings suggest that DPN had more common and severe peroneal nerve involvement in the motor nerve conduction studies (MNCS). These findings have important implications for the electrophysiological evaluation of DPN.
Diabetic Polyneuropathy;Motor Nerve Conduction Studies;Peroneal Nerve
- P. Noel, "Sensory nerve conduction in the upper limbs at various stages of diabetic neuropathy," J Neurol Neurosurg Psychiatry, Vol.36, No.5, pp.786-796, 1973. https://doi.org/10.1136/jnnp.36.5.786
- R. J. Graf, J. B. Halter, and E. Halar, "Nerve conduction abnormalities in untreated maturity-onset diabetes: relation to levels of fasting plasma glucose and glycosylated hemoglobin," Ann Intern Med, Vol.90, No.3, pp.298-303, 1979. https://doi.org/10.7326/0003-4819-90-3-298
- E. Rota, R. Quadri, and E. Fanti, "Electrophysiological findings of peripheral neuropathy in newly diagnosed type II diabetes mellitus," Journal of the Peripheral Nervous System, Vol.10, No.4, pp.348-353, 2005. https://doi.org/10.1111/j.1085-9489.2005.00046.x
- M. S. Liu, B. L. Hu, and L. Y. Cui, "Clinical and neurophysiological features of 700 patients with diabetic peripheral neuropathy," Zhonghua Nei KeZa Zhi, Vol.44, No.3, pp.173-176, 2005.
- S. Karsidag, S. Morali, and M. Sargin, "The electrophysiological findings of subclinical neuropathy in patients with recently diagnosed type 1 diabetes mellitus," Diabetes Research and Clinical Practice, Vol.67, No.3, pp.211-219, 2005. https://doi.org/10.1016/j.diabres.2004.07.017
- G. Said, "Diabetic neuropathy; a review," Nat Clin Pract Neurol, Vol.3, No.6, pp.331-340, 2007. https://doi.org/10.1038/ncpneuro0504
- P. H. Hendriksen, P. L. Oey, and G. H. Wieneke, "Subclinical diabetic polyneuropathy; early detection of involvement of different nerve fibre types," J Neurol Neurosurg Psychiatry, Vol.56, No.5, pp.509-514, 1993. https://doi.org/10.1136/jnnp.56.5.509
- Z. Li, X. Hu, and N. Tang, "Significance of nueroelectrophysiological tests in the early diagnosis of sub-clinical neuropathay with diabe-tes mellitus," J Huazhong Univ Sci Technolog Med Sci, Vol.26, No.4, pp.429-431, 2006. https://doi.org/10.1007/s11596-006-0413-y
- A. Asad, M. A. Hameed, and U. A. Khan, "Comparison of nerve conduction studies with diabetic neuropathy symptom score and diabetic neuropathy examination score in type-2 diabetics for detection of sensorimotor polyneuropathy," J Pak Med Assoc, Vol.59, No.9, pp.594-598, 2009.
- P. J. Dyck, C. J. Overland, and P. A. Low, "Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorymotor polyneuro-pathy: Cl Vs. NPhys Trial," Muscle Nerve, Vol.42, No.2, pp.157-164, 2010. https://doi.org/10.1002/mus.21661
- S. R. Abu-Shakra, D. R. Cornblath, and O. L. Avila, "Conduction block in diabetic neuropathy," Muscle Nerve, Vol.14, No.9, pp.858-862, 1991. https://doi.org/10.1002/mus.880140910
- S. J. Oh, "Clinical electromyography: Nerve cond-uction studies," third edition, Lippincott Williams & Wilkins, Philadelphia, U.S.A, pp.86-135, 2003.
- R. L. Braddom, J. B. Hollis, and D. O. Castell, "Diabetic peripheral neuropathy; a correlation of nerve conduction studies and clinical findings," Arch Phys Med Rehab, Vol.58, No.7, pp.308-313, 1977.
- R. Celiker, O. Basgoze, and M. Bayraktar, "Early detection of neurological involvement in diabetes mellitus," Electromyo Clin Neurophysiol, Vol.36, No.1, pp.29-35, 1996.
- G. Felsenthal and M. E. McIvor, "Reappraisal of the electroneurographic and electromyographic diag-nosis of diabetic peripheral neuropathy," Am J Phys Med, Vol.63, No.6, pp.278-288, 1984.
- P. J. Dyck, J. L. Karnes, and P. C. O'Brien, "The Rochester diabetic neuropathy study: reassess-ment of tests and criteria for diagnosis and staged severity," Neurology, Vol.42, No.6, pp.1164-70, 1992. https://doi.org/10.1212/WNL.42.6.1164