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Bioactivities of the Herb Extracts Used for Gamhongroju, a Korean Liqueur

  • Lee, Sae-Rom (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Jung, Ha-Na (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Cho, Hyunn-Ho (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Jhin, Chang-Ho (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Hwang, Keum-Taek (Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University) ;
  • Jeong, Seok-Tae (Fermentation & Food Processing Division, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Tae-Young (Fermentation & Food Processing Division, National Academy of Agricultural Science, Rural Development Administration)
  • Received : 2011.07.27
  • Accepted : 2011.10.01
  • Published : 2011.12.31

Abstract

In this study, antioxidative and anti-inflammatory activities of the herb (cinnamon, clove, glehnia root, ginger, violet-root cromwell, licorice, citrus peel and longan) extracts used for gamhongroju, one of the popular liqueurs in Korea, were investigated. Twenty grams of individual herbs were extracted in 60% purified ethanol and freeze-dried. A mixture of the individual herb extracts (HEM) was separately prepared. Cytotoxicity of the individual extracts and HEM on murine RAW264.7 macrophage cells were examined along with their recovering activity on $H_2O_2$-treated RAW264.7 cells. Antioxidant and anti-inflammatory activities of the extract-treated cells were determined by measuring superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, and Trolox equivalent antioxidant capacity (TEAC), nitric oxide (NO) and prostaglandin E2 (PGE2) levels. Violet-root cromwell extract showed the least cytotoxicity in terms of treated concentration. Most of the extracts, below levels of cytotoxicity, recovered the $H_2O_2$-treated cells. Treatment with some of the extracts increased SOD and GPx activities and TEAC levels while a majority inhibited the production of NO and PGE2 in lipopolysaccharide (LPS)-treated cells.

Acknowledgement

Supported by : RDA

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