Synthesis and Characterization of Lactobionic Acid Grafted Phenylalanyl-Glycyl-Chitosan

  • Li, He-Ping ;
  • Li, Shan ;
  • Wang, Zhou-Dong ;
  • Qin, Long
  • Received : 2011.06.29
  • Accepted : 2011.09.14
  • Published : 2011.12.20


In order to enhance the target action of chitosan-based drug, this paper firstly prepared phenylalanyl-glycylchitosan (Phe-Gly-CS) by grafting the key intermediate, bromoacetyl-phenylalanine (BA-Phe) onto chitosan. Then the target sugar molecule, lactobionic acid (LA), was grafted to Phe-Gly-CS and the topic compound lactobionic acid grafted phenylalanyl-glycyl-chitosan (Phe-Gly-CS-LA) was finally obtained in a yield of 78.8%. The product were characterized by FTIR, MS and 1H NMR. The preparing condition of BA-Phe was optimized as follows: the best pH was 10-11, the optimum temperature was $-4^{\circ}C$, the reaction time was 1.5 h.


Grafted chitosan;Drug carrier;prepare;Lactobionic acid


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Supported by : National Natural Science Foundation of China, Natural Science Foundation of Hunan Province of China