Studies on Some Bioactive 1,1-Bis(2-benzylidene-5-aryliden-1,3-thiadiazolidin-4-one)cyclopropane

  • Panwar, Hemant ;
  • Chaudhary, Nidhi ;
  • Singh, Sachi ;
  • Chawla, Amit
  • Received : 2011.07.27
  • Accepted : 2011.09.28
  • Published : 2011.12.20


Some novel heterocyclic derivatives of 1,1-bis(2-phenyl-5-arylidine-1,3-thiadiazolidin-4-one)cyclopropane 4(a-i) have been synthesized from cyclopropane dicarboxylic acid and substituted thiadiazole moieties. All the synthesized compounds have been characterized by elemental and spectral (I.R., $^1H$-NMR, Mass) analysis. Furthermore, above said compounds were screened for their antifungal and antibacterial activities. Compound 4c was found the most potent one which further evaluated for lesser toxicity test.


Bis-phenylarylidinylthiadiazolidinone cyclopropane;Antifungal;Antibacterial;Acute toxicity


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