Association of GNB3 Polymorphism with Obesity Index, Blood Pressure, Glucose and Lipid Level

비만한 한국인에서 GNB3 유전자다형성과 비만 지표, 혈압, 혈당, 지질 대사의 관계

  • Kwon, Dong-Hyun (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University) ;
  • Park, Jung-Hyun (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University) ;
  • Lee, Myeong-Jong (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University) ;
  • Song, Mi-Young (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University) ;
  • Kim, Ho-Jun (Dept. of Oriental Rehabilitation Medicine, Graduate School, Dong-Guk University)
  • 권동현 (동국대학교 한의과대학 한방재활의학교실) ;
  • 박정현 (동국대학교 한의과대학 한방재활의학교실) ;
  • 이명종 (동국대학교 한의과대학 한방재활의학교실) ;
  • 송미영 (동국대학교 한의과대학 한방재활의학교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학교실)
  • Received : 2011.09.15
  • Accepted : 2011.10.13
  • Published : 2011.10.30

Abstract

Objectives: The aim of this study is to establish the association of GNB3 with obesity-index, blood pressure, glucose and lipid level. Methods: A total of 209 Korean obese subjects participated in the study. Body weight, body mass index(BMI), waist circumference, body fat, body fat mass, resting metabolic rate, blood pressure, total cholesterol, high density lipoprotein, triglyceride and fasting blood sugar test were measured by using standardized protocols. The GNB3 was genotyped by using polymerase chain reaction with restriction fragment length polymorphism. Results: The frequency of CC, CT, TT genotype were, respectively, 18,2%, 56.9%, 24,9%, and the frequency of T allele was 53.3% in Korean obese population. There were no association of GNB3 with obesity index, blood pressure, glucose and lipid level in Korean obese population. Conclusions: Obese Korea population have a higher frequency of T alle than general Korean population. There are no association of GNB3 with obesity index, blood pressure, glucose and lipid level in Korean obese population.

Acknowledgement

Supported by : 보건복지가족부, (주)한국인삼공사

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