Single Oral Dose Toxicity of TB001 in Rats

백서에서 식품 복합물 TB001의 단회 경구투여 독성 시험 연구

  • Cha, Yun-Yeop (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sang-Ji University) ;
  • Sun, Seung-Ho (Dept. of Oriental internal Medicine, College of Oriental Medicine, Sang-Ji University) ;
  • Park, Won-Hyung (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sang-Ji University) ;
  • Park, Dong-Sik (Functional Food and Nutrition Division, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Jae-Hyun (Functional Food and Nutrition Division, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Hee-Yeon (Gangwon Provincial Agricultural Research & Extention Services) ;
  • Lim, Sang-Hyun (Gangwon Provincial Agricultural Research & Extention Services) ;
  • Kim, Kyung-Hee (Gangwon Provincial Agricultural Research & Extention Services)
  • 차윤엽 (상지대학교 한의과대학 한방재활의학과교실) ;
  • 선승호 (상지대학교 한의과대학 한방내과학교실) ;
  • 박원형 (상지대학교 한의과대학 한방재활의학과교실) ;
  • 박동식 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김재현 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김희연 (강원도 농업기술원 농산물이용시험장) ;
  • 임상현 (강원도 농업기술원 농산물이용시험장) ;
  • 김경희 (강원도 농업기술원 농산물이용시험장)
  • Received : 2011.09.14
  • Accepted : 2011.10.05
  • Published : 2011.10.30

Abstract

Objectives: This study was performed to investigate single oral dose toxicity of TB001, the extract mixture of Purple loosestrife and Aceriphyllum rossii. Methods: The mortality, general symptom, change of weight: and necropcy findings was investigated for 14 days after a dose(2000 mg/kg B.W.) of TB001 was given, using SD rats of both male and female according to "The guideline of toxicity test for medicine and others". Results: The death of rats and abnormal finding was not observed. There was no the significant difference of weight between control group and TB001 group. Conclusions: The abnormalities at the necropsy finding of all survived rats was not detected. The study suggested that there is no toxicity in single dose(2000 mg/kg B.W.) of TB001.

Acknowledgement

Supported by : 농촌진흥청

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