Maximum Tolerated Dose Estimate by Curve Fitting in Phase I Clinical Trial

제1상 임상시험에서 곡선적합을 이용한 MTD 추정법

Heo, Eun-Ha;Kim, Dong-Jae

  • Received : 20100900
  • Accepted : 20111100
  • Published : 2011.03.31


The purpose of a Phase I clinical trial is to estimate the maximum tolerated dose, MTD, of a new drug. In this paper, the MTD estimation method is suggested by curve fitting the dose-toxicity data to an S-shaped curve. The suggested MTD estimation method is compared with established MTD estimation procedures using a Monte Carlo simulation study.


Phase I clinical trial;Maximum tolerated dose(MTD);dose-toxicity curve


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