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Hypoglycemic Effects of a Medicinal Herb Mixture Prepared through the Traditional Antidiabetic Prescription

당뇨 처방에 근거한 생약재 복합물의 혈당강하 효과

  • Kim, Jung-Ok (Daegu Gyeongbuk Institute for Oriental Medicine Industry) ;
  • Lee, Gee-Dong (Major of Nutrition Education, Graduate School of Education, Joongbu University)
  • 김정옥 (대구경북한방산업진흥원) ;
  • 이기동 (중부대학교 교육대학원 영양교육전공)
  • Received : 2011.07.07
  • Accepted : 2011.12.09
  • Published : 2011.12.30

Abstract

For the purpose of investigating the in vitro antidiabetic activity of a medicinal herb mixture prepared through traditional antidiabetic prescription, the study analyzed the existence of insulin-similar components and examined ${\alpha}$-amylase and ${\alpha}$-glucosidase inhibition activity. As a result of arranging the medicinal herb mixture extracts over the 3T3-L1 fibroblast in the concentration of $10{\mu}g/mL$, which confirmed that it included much of insulin sensitizer components as 151.7% in the differentiation of 3T3-L1 fibroblast. The inhibition activity against ${\alpha}$-amylase of the medicinal herb mixture extracts as hypoglycemic agent were 38.4, 31.5 and 16.6% in the concentration of 10.0, 1.0 and 0.1 mg/mL, respectively. The inhibition activity against ${\alpha}$-glucosidase of the medicinal herb mixture extracts were 81.3, 35.8 and 26.7% in the concentration of 10.0, 1.0 and 0.1 mg/mL, respectively. The inhibition activity against ${\alpha}$-glucosidase in the ethyl acetate fractions of the water and 80% ethanol extracts were 66.9% and 55.1%, respectively, the highest levels in the various solvent extracts.

Acknowledgement

Supported by : 지식경제부

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