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Ovalbumin Induces Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression

Ovalbumin에 의한 cyclooxygenase-2와 inducible nitric oxide synthase 유도

  • Lee, A-Neum (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Park, Se-Jeong (Department of Medical Science, College of Medical Sciences, Soonchunhyang University) ;
  • Jeong, Ae-Ri (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Lee, Jae-Ran (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Park, Hye-Jeong (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Kim, Soo-Jung (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Min, In-Soon (Department of Healthcare Management, College of Medical Sciences, Soonchunhyang University) ;
  • Youn, Hyung-Sun (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University)
  • 이아늠 (순천향대학교 의료과학대학 임상병리학과) ;
  • 박세정 (순천향대학교 의료과학대학 의료과학과) ;
  • 정애리 (순천향대학교 의료과학대학 임상병리학과) ;
  • 이재란 (순천향대학교 의료과학대학 임상병리학과) ;
  • 박혜정 (순천향대학교 의료과학대학 임상병리학과) ;
  • 김수정 (순천향대학교 의료과학대학 임상병리학과) ;
  • 민인순 (순천향대학교 의료과학대학 보건행정경영학과) ;
  • 윤형선 (순천향대학교 의료과학대학 임상병리학과)
  • Received : 2010.09.03
  • Accepted : 2010.11.16
  • Published : 2011.02.28

Abstract

Egg allergies are the most prevalent food hypersensitivity in children. The major egg allergens are proteins, such as ovalbumin (OVA) and ovomucoid (OVM), which are mainly contained in egg whites. OVA is the major protein in egg white, comprising 54% of the total protein content. OVA has been widely used in experimental inhalant and dietary allergy animal models, but its mechanism has not been clearly identified. In this study, we showed that OVA induced nuclear factor-${\kappa}B$ activation. OVA also induced the expression of cyclooxygenase-2 and inducible nitric oxide synthase. These data suggest new approaches for developing efficient anti-allergic strategies.

Keywords

ovalbumin;egg allergy;$NF-{\kappa}B$;cyclooxygenase-2;inducible nitric oxide synthase

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