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Ovalbumin에 의한 cyclooxygenase-2와 inducible nitric oxide synthase 유도

Ovalbumin Induces Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression

  • 이아늠 (순천향대학교 의료과학대학 임상병리학과) ;
  • 박세정 (순천향대학교 의료과학대학 의료과학과) ;
  • 정애리 (순천향대학교 의료과학대학 임상병리학과) ;
  • 이재란 (순천향대학교 의료과학대학 임상병리학과) ;
  • 박혜정 (순천향대학교 의료과학대학 임상병리학과) ;
  • 김수정 (순천향대학교 의료과학대학 임상병리학과) ;
  • 민인순 (순천향대학교 의료과학대학 보건행정경영학과) ;
  • 윤형선 (순천향대학교 의료과학대학 임상병리학과)
  • Lee, A-Neum (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Park, Se-Jeong (Department of Medical Science, College of Medical Sciences, Soonchunhyang University) ;
  • Jeong, Ae-Ri (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Lee, Jae-Ran (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Park, Hye-Jeong (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Kim, Soo-Jung (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) ;
  • Min, In-Soon (Department of Healthcare Management, College of Medical Sciences, Soonchunhyang University) ;
  • Youn, Hyung-Sun (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University)
  • 투고 : 2010.09.03
  • 심사 : 2010.11.16
  • 발행 : 2011.02.28

초록

음식 알러지는 만성적인 장애를 일으킬 수 있는 즉각적이며 잠재적으로 생명을 위협하는 반응이다. 이 중 계란은 알러지 위험성이 높은 물질로, 아이들에게 음식 알러지를 유발하는 흔한 물질로 알려져 있다. 계란 알러젠 중에서 계란 흰자 단백질인 OVA이 주요한 알러젠으로 알려져 있다. 우리는 이번 연구에서 OVA이 염증 및 면역 반응에 중요한 역할을 한다고 알려져 있는 $NF-{\kappa}B$ 활성화와 COX-2와 iNOS 발현에 어떠한 영향을 미치는지를 알아보았다. OVA은 $NF-{\kappa}B$ 활성화와 COX-2와 iNOS의 발현을 증가시켰다. 이러한 연구는 앞으로 계란 알러젠에 의한 알러지 작용기전 규명 및 알러지 치료제 개발에 중요한 역할을 할 것으로 기대한다.

키워드

ovalbumin;egg allergy;$NF-{\kappa}B$;cyclooxygenase-2;inducible nitric oxide synthase

참고문헌

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피인용 문헌

  1. Phenethyl Isothiocyanate Inhibits Ovalbumin-induced Inducible Nitric Oxide Synthase Expression vol.44, pp.6, 2012, https://doi.org/10.9721/KJFST.2012.44.6.759
  2. Anti-inflammatory Effects of Aster yomena Extracts by the Suppression of Inducible Nitric Oxide Synthase Expression vol.23, pp.2, 2017, https://doi.org/10.15616/BSL.2017.23.2.104