A Comparison Study on SVM MDR and D-MDR for Detecting Gene-Gene Interaction in Continuous Data

연속형자료의 유전자 상호작용 규명을 위한 SVM MDR과 D-MDR의 방법 비교

  • Received : 20110100
  • Accepted : 20110500
  • Published : 2011.07.31


We have used a multifactor dimensionality reduction(MDR) method to study the major gene interaction effect in general; however, without application of the MDR method in continuous data. In light of this, many methods have been suggested such as Expanded MDR, Dummy MDR and SVM MDR. In this paper, we compare the two methods of SVM MDR and D-MDR. In addition, we identify the gene-gene interaction effect of single nucleotide polymorphisms(SNPs) associated with economic traits in Hanwoo(Korean cattle). Lastly, we discuss a new method in consideration of the advantages that the other methods present.


Gene-gene interaction;MDR method;SNP;SVM algorithm;Dummy MDR;Multifactor Dimensionality Reduction(MDR);SVM


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