Central diabetic insipidus associated with suspected pituitary gland tumor in a dog

  • Lee, Kyo-Im (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Received : 2011.08.30
  • Accepted : 2011.11.30
  • Published : 2011.12.30


A 12-year-old spayed female Yorkshire terrier dog was presented with two-weeks history of lethargy, mental dullness and polydipsia. Neurologic examination revealed proprioceptive defect of all limbs and loss of swallowing gag reflex. The dog revealed persistent dehydration, hypernatremia, hyperosmolarity and hyposthenuria. On magnetic resornance imaging (MRI), the mass were heterogeneous signality on T1 weighted images, hyperintense signality on T2 weighted image with contrast enhancement on hypothalamohypophyseal lesion. Based on these findings, the dog was suspected as having pituitary gland tumor. Through water deprivation test and response to desmopressin acetate (1-deamino-8-D-arginine, DDAVP), this case was diagnosed by central diabetes insipidus (CDI). This paper reports the clinical sign, MRI, response to the exogenous antidiuretic hormone of CDI due to suspected pituitary tumor in a dog and DDAVP administration was evaluated effective therapy to correct hypernatremia induced by CDI.


Supported by : Brain Korea 21


  1. Abelson AL, Faissler D, Karas AZ. Anesthesia case of the month. Development of the Cushing reflex secondary to a dangerous increase in intracranial pressure. J Am Vet Med Assoc 2008, 232, 1298-1300.
  2. Aroch I, Mazaki-Tovi M, Shemesh O, Sarfaty H, Segev G. Central diabetes insipidus in five cats: clinical presentation, diagnosis and oral desmopressin therapy. J Feline Med Surg 2005, 7, 333-339.
  3. Authement JM, Boudrieau RJ, Kaplan PM. Transient, traumatically induced, central diabetes insipidus in a dog. J Am Vet Med Assoc 1989, 194, 683-685.
  4. Cohen M, Post GS. Nephrogenic diabetes insipidus in a dog with intestinal leiomyosarcoma. J Am Vet Med Assoc 1999, 215, 1818-1820.
  5. Cote E. Clinical Veterinary Advisor: Dog and Cat. 1st ed. pp. 1342, Mosby, St. Louis, 2007.
  6. Court MH, Watson AD. Idiopathic neurogenic diabetes insipidus in a cat. Aust Vet J 1983, 60, 245-247.
  7. DiBartola SP. Renal disease: clinical approach and laboratory evaluation. In: Ettinger SJ, Feldman EC (eds.). Textbook of Veterinary Internal Medicine. 6th ed. pp. 1716-1722, Elsevier, St. Louis, 2005.
  8. Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction. 3rd ed. pp. 2-44, Saunders, St. Louis, 2004.
  9. Foley C, Bracker K, Drellich S. Hypothalamicpituitary axis deficiency following traumatic brain injury in a dog. J Vet Emerg Crit Care (San Antonio) 2009, 19, 269-274.
  10. Ferguson DC, Biery DN. Diabetes insipidus and hyperadrenocorticism associated with high plasma adrenocorticotropin concentration and a hypothalamic/ pituitary mass in a dog. J Am Vet Med Assoc 1988, 193, 835-839.
  11. Green RA, Farrow CS. Diabetes insipidus in a cat. J Am Vet Med Assoc 1974, 164, 524-526.
  12. Hara Y, Masuda H, Taoda T, Hasegawa D, Fujita Y, Nezu Y, Tagawa M. Prophylactic efficacy of desmopressin acetate for diabetes insipidus after hypophysectomy in the dog. J Vet Med Sci 2003, 65, 17-22.
  13. Harb MF, Nelson RW, Feldman EC, Scott- Moncrieff JC, Griffey SM. Central diabetes insipidus in dogs: 20 cases (1986-1995). J Am Vet Med Assoc 1996, 209, 1884-1888.
  14. Lam KS, Wat MS, Choi KL, Ip TP, Pang RW, Kumana CR. Pharmacokinetics, pharmacodynamics, long-term efficacy and safety of oral 1-deamino-8-Darginine vasopressin in adult patients with central diabetes insipidus. Br J Clin Pharmacol 1996, 42, 379-385.
  15. Mavrakis AN, Tritos NA. Diabetes insipidus with deficient thirst: report of a patient and review of the literature. Am J Kidney Dis 2008, 51, 851-859.
  16. Mellanby RJ, Jeffery ND, Gopal MS, Herrtage ME. Secondary hypothyroidism following head trauma in a cat. J Feline Med Surg 2005, 7, 135-139.
  17. Mulnix JA, Rijnberk A, Hendriks HJ. Evaluation of a modified water-deprivation test for diagnosis of polyuric disorders in dogs. J Am Vet Med Assoc 1976, 169, 1327-1330.
  18. Neer TM, Reavis DU. Craniopharyngioma and associated central diabetes insipidus and hypothyroidism in a dog. J Am Vet Med Assoc 1983, 182, 519-520.
  19. Nichols R, Hohenhaus AE. Use of the vasopressin analogue desmopressin for polyuria and bleeding disorders. J Am Vet Med Assoc 1994, 205, 168-173.
  20. Ozdemir O, Hachinski V. Brain lateralization and sudden death: its role in the neurogenic heart syndrome. J Neurol Sci 2008, 268, 6-11.
  21. Platt SR, Chrisman CL, Graham J, Clemmons RM. Secondary hypoadrenocorticism associated with craniocerebral trauma in a dog. J Am Anim Hosp Assoc 1999, 35, 117-122.
  22. Pollard RE, Reilly CM, Uerling MR, Wood FD, Feldman EC. Cross-sectional imaging characteristics of pituitary adenomas, invasive adenomas and adenocarcinomas in dogs: 33 cases (1988-2006). J Vet Intern Med 2010, 24, 160-165.
  23. Post K, McNeill JR, Clark EG, Dignean MA, Olynyk GP. Congenital central diabetes insipidus in two sibling Afghan hound pups. J Am Vet Med Assoc 1989, 194, 1086-1088.
  24. Ramsey IK, Dennis R, Herrtage ME. Concurrent central diabetes insipidus and panhypopituitarism in a German shepherd dog. J Small Anim Pract 1999, 40, 271-274.
  25. Rijnberk A. Diabetes insipidus. In: Ettinger SJ, Feldman EC (eds.). Textbook of Veterinary Internal Medicine. 6th ed. pp. 1504-1505, Elsevier, St. Louis, 2005.
  26. Thayer JF, Lane RD. Claude Bernard and the heartbrain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev 2009, 33, 81-88.
  27. Thomason JD, Kraus MS, Surdyk KK, Fallaw T, Calvert CA. Bradycardia-associated syncope in 7 Boxers with ventricular tachycardia (2002-2005). J Vet Intern Med 2008, 22, 931-936.
  28. van Vonderen IK, Wolfswinkel J, Oosterlaken- Dijksterhuis MA, Rijnberk A, Kooistra HS. Pulsatile secretion pattern of vasopressin under basal conditions, after water deprivation, and during osmotic stimulation in dogs. Domest Anim Endocrinol 2004, 27, 1-12.
  29. Vincent JL, Su F. Physiology and pathophysiology of the vasopressinergic system. Best Pract Res Clin Anaesthesiol 2008, 22, 243-252.
  30. Wan WH, Ang BT, Wang E. The Cushing Response: a case for a review of its role as a physiological reflex. J Clin Neurosci 2008, 15, 223-228.