Anti-allergic Effects of Schizonepeta tenuifolia on Mast Cell-Mediated Allergy Model

  • Yoo, Jin-Su (College of Pharmacy, Woosuk University) ;
  • Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
  • Kim, Sang-Hyun (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Shin, Tae-Yong (College of Pharmacy, Woosuk University)
  • Received : 2011.05.12
  • Accepted : 2011.09.04
  • Published : 2011.09.30

Abstract

Immediate-type hypersensitivity is involved in many allergic diseases such as asthma, allergic rhinitis and anaphylaxis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells releases inflammatory mediators, such as histamine and pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of the aqueous extract of Schizonepeta tenuifolia (AEST) (Labiatae) on the immediate-type allergic reaction. AEST inhibited compound 48/80-induced systemic allergic reaction. AEST attenuated immunoglobulin E (IgE)-mediated skin allergic reaction and histamine release from human mast cell line (HMC-1) cells. In addition, AEST decreased the gene expression and secretion of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated HMC-1 cells. Our results indicate that AEST inhibits the mast cell-derived allergic reactions and involvement of histamine and pro-inflammatory cytokines in these effects.

Acknowledgement

Supported by : Woosuk University

References

  1. Bradding, P., Feather, I.H., Wilson, S., Bardin, P.G., Heusser, C.H., Holgate, S.T., and Howarh, P.H., Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J. Immunol. 151, 3853-3865 (1993).
  2. Brown, J.M., Wilson, T.M., and Metcalfe, D.D., The mast cell and allergic diseases: role in pathogenesis and implications for therapy. Clin. Exp. Allergy 38, 4-18(2008).
  3. Fung, D. and Lau, C.B., Schizonefeta tenuifolia: chemistry, pharmacology, and clinical applications. J. Clin. Pharmacol. 42, 30-36 (2002). https://doi.org/10.1177/0091270002042001003
  4. Galli, S.J., Gordon, J.R., and Wershil, B.K., Cytokine production by mast cells and basophils. Curr. Opin. Immunol. 3, 865-872(1991). https://doi.org/10.1016/S0952-7915(05)80005-6
  5. Galli, S.J., Tsai, M., and Piliponsky, A.M., The development of allergic inflammation. Nature 454, 445-454 (2008). https://doi.org/10.1038/nature07204
  6. Kang, H., Oh, Y.J., Choi, H.Y., Ham, I.H., Bae, H.S., Kim, S.H., and Ahn, K.S., Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro. J. Pharm. Pharmacol. 60(7), 901-907 (2008). https://doi.org/10.1211/jpp.60.7.0012
  7. Kemp, S.F., and Lockey, R.F., Anaphylaxis: a review of causes and mechanisms. J. Allergy Clin. Immunol. 110, 341-348 (2002). https://doi.org/10.1067/mai.2002.126811
  8. Kim, S.J., Kim, J.S., Choi, I.Y., Kim, D.H., Kim, M.C., An, H.J., Na, H.J., Kim, N.H., Moon, P.D., Myung, N.Y., Lee, J.Y., Jeong, H.J., Um, J.Y., Shin, T.Y., Kim, H.M., and Hong, S.H., Anti-inflammatory activity of Schizonepeta tenuifolia through the inhibition of MAPK phosphorylation in mouse peritoneal macrophages. Am. J. Chin. Med. 36(6), 1145-1158(2008). https://doi.org/10.1142/S0192415X0800648X
  9. Kim, S.H. and Sharma, R.P., Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling. Toxicol. Appl. Pharmacol. 196, 47-57 (2004). https://doi.org/10.1016/j.taap.2003.11.020
  10. Kim, S.H. and Shin, T.Y., Anti-inflammatory effect of leaves of Eriobotrya japonica correlating with attenuation of p38 MAPK, ERK, and NF-$\kappaB$ activation in mast cells. Toxicol. in Vitro 23, 1215-1219 (2009). https://doi.org/10.1016/j.tiv.2009.07.036
  11. Kim, S.H., Jun, C.D., Suk, K., Choi, B.J., Lim, H., Park, S., Lee, S.H., Shin, H.Y., Kim, D.K., and Shin, T.Y., Gallic acid inhibits histamine release and proinflammatory cytokine production in mast cells. Toxicol. Sci. 91, 123-131 (2006). https://doi.org/10.1093/toxsci/kfj063
  12. Kim, S.H. and Shin, T.Y., Effect of Dracocephalum argunense on mast cell-mediated hypersensitivity. Int. Arch. Allergy Immunol. 139, 87-95 (2006). https://doi.org/10.1159/000090383
  13. Kimura, T., But, P.P.H., Guo, J.X., Sung, C.K., and Han, B.H., International Collation of Traditional and Folk Medicine (1), World Scientific, Singapore, 1986, pp.147-148.
  14. Metcalfe, D.D., Peavy, R.D., and Gilfillan, A.M., Mechanism of mast cell signaling in anaphylaxis. J. Allergy Clin. Immunol. 124, 639-646 (2009). https://doi.org/10.1016/j.jaci.2009.08.035
  15. Mican, J.A., Arora, N., Burd, P.R., and Metcalfe, D.D., Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein. J. Allergy Clin. Immunol. 90, 815-824 (1992). https://doi.org/10.1016/0091-6749(92)90107-D
  16. Mousli, M.C., Bronner, C., Bockaert, J., Rouot, B., and Landry, Y., Interaction of substance P, compound 48/80 and mastoparan with asubunit C-terminal of G protein. Immunol. Lett. 25, 355-358 (1990). https://doi.org/10.1016/0165-2478(90)90207-7
  17. Rao, K.N. and Brown, M.A., Mast cells: multifaceted immune cells with diverse roles in health and disease. Ann. N. Y. Acad. Sci. 1143, 83-104(2008). https://doi.org/10.1196/annals.1443.023
  18. Shin, T.Y., Kim, S.H., Choi, C.H., Shin, H.Y., and Kim, H.M., Isodon japonicus decreases immediate-type allergic reaction and tumor necrosis factor-alpha production. Int. Arch. Allergy Immunol. 135, 17-23 (2004). https://doi.org/10.1159/000080038
  19. Shin, T.Y., Kim, S.H., Suk, K., Ha, J.H., Kim, I., Lee, M.G., Jun, C.D., Kim, S.Y., Lim, J.P., Eun, J.S., Shin, H.Y., and Kim, H.M., Antiallergic effects of Lycopus lucidus on mast cell-mediated allergy model. Toxicol. Appl. Pharmacol. 209, 255-262 (2005). https://doi.org/10.1016/j.taap.2005.04.011
  20. Shin, T.Y., Oh, J.M., Choi, B.J., Park, W.H., Kim, C.H., Jun, C.D., and Kim, S.H., Anti-inflammatory effect of Poncirus trifoliata fruit through inhibition of NF-$\kappaB$ activation in mast cells. Toxicol. in Vivo 20, 1071-1076 (2006).
  21. Sillaber, C., Bevec, D., Butterfield, J.H., Heppner, C., Valenta, R., Scheiner, O., Kraft, D., Lechner, K., Bettelheim, P., and Valent, P., Tumor necrosis factor alpha and interleukin-1 beta mRNA expression in HMC-1 cells: differential regulation of gene product expression by recombinant interleukin-4. Exp. Hematol. 21, 1271-1275 (1993).
  22. Walsh, L.J., Trinchieri, G., Waldorf, H.A., Whitaker, D., and Murphy, G.F., Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc. Natl. Acad. Sci. 88, 4220-4224 (1991). https://doi.org/10.1073/pnas.88.10.4220