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Exploration of the Gene-Gene Interactions Using the Relative Risks in Distinct Genotypes

유전자형별 상대 위험도를 이용한 유전자-유전자간 상호작용 탐색

Jung, Ji-Won;Yee, Jae-Yong;Lee, Suk-Hoon;Pa, Mi-Ra
정지원;이재용;이석훈;박미라

  • Received : 20110700
  • Accepted : 20110900
  • Published : 2011.10.31

Abstract

One of the main objects of recent genetic studies is to understand genetic factors that induce complex diseases. If there are interactions between loci, it is difficult to find such associations through a single-locus analysis strategy. Thus we need to consider the gene-gene interactions and/or gene-environment interactions. The MDR(multifactor dimensionality reduction) method is being used frequently; however, it is not appropriate to detect interactions caused by a small fraction of the possible genotype pairs. In this study, we propose a relative risk interaction explorer that detects interactions through the calculation of the relative risks between the control and disease groups from each genetic combinations. For illustration, we apply this method to MDR open source data. We also compare the MDR and the proposed method using the simulated data eight genetic models.

Keywords

Gene-gene interaction;relative risk;genetic model;MDR

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Cited by

  1. Detecting Genetic Association and Gene-Gene Interaction using Network Analysis in Case-Control Study vol.25, pp.4, 2012, https://doi.org/10.5351/KJAS.2012.25.4.563

Acknowledgement

Supported by : 한국연구재단