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Drug-release Properties of Double-layered Microspherical Carriers which Consist of Outer Shell of Poly(D,L-lactide) and Inner Core of Alginate or Chitosan

Poly(D,L-lactide)를 외부 껍질로 하고 Alginate 또는 Chitosan을 내부 코어로 구성한 이중미립구 담체의 약물방출 특성

  • Kim, Ja Won (Dept. of Health Technology, Pusan National University) ;
  • Song, Min Jeong (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Lee, Sang Min (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Lim, So Ryong (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Jung, Su Jin (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Kim, Hong Sung (Dept. of Biomaterial Engineering, Pusan National University)
  • 김자원 (부산대학교 헬스테크놀로지 협동과정) ;
  • 송민정 (부산대학교 바이오소재과학과) ;
  • 이상민 (부산대학교 바이오소재과학과) ;
  • 임소령 (부산대학교 바이오소재과학과) ;
  • 정수진 (부산대학교 바이오소재과학과) ;
  • 김홍성 (부산대학교 바이오소재과학과)
  • Received : 2012.04.05
  • Accepted : 2012.06.04
  • Published : 2012.11.25

Abstract

Double-layered polymeric carrier was designed for release control of hydrophilic drug in oral administration. Biopolymeric chitosan and alginate were examined as polar absorbents, poly(D,L-lactide) as a hydrophobic shell, and theophylline and diclofenac sodium as loading drugs. The fabrication of the carriers was prepared in the form of double-layered microsphere for delayed and successively extended release, which consisted of outer shell of poly(D,L-lactide) and inner core of alginate or chitosan with drugs. Morphologies and drug-release behaviors of the carriers were investigated, which were influenced by a combination of polarity between carrier and drug. It was confirmed that the relative polarities of the carriers, the drugs, and the environmental pH affected significantly the drug-release property.

Acknowledgement

Supported by : 부산대학교

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