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Effect of Scolopendrid Calculus Bovis-Fel Uris-Moschus Bee Venom and Sweet Bee Venom on Regional Cerebral Blood Flow after Pharmacopuncture to GV16 Pungbu and GB20 Pungji in Rat

  • Park, Soo-Jung (Department of Sasang Constitutional Medicine, Wonkwang University Oriental Medical Hospital) ;
  • Lee, Ho-Young (Department of Sasang Constitutional Medicine, Wonkwang University College of Oriental Medicine) ;
  • Yoon, Tak-Hyun (Department of Sasang Constitutional Medicine, Wonkwang University College of Oriental Medicine) ;
  • Joo, Jong-Cheon (Department of Sasang Constitutional Medicine, Wonkwang University Oriental Medical Hospital)
  • Received : 2012.10.25
  • Accepted : 2012.11.06
  • Published : 2012.12.31

Abstract

Objectives: This study was designed to investigate the effect of four pharmacopuncture drugs (scolopendrid, Calculus Bovis-Fel Uris-Moschus (BUM), bee venom 25%, and sweet bee venom 10%) on the cerebral hemodynamics, including changes in the regional cerebral blood flow (rCBF) and in the mean arterial blood pressure (MABP). Methods: The changes in the rCBF and the MABP were determined by using a laser-Doppler flowmeter and a pressure transducer, respectively. Results: Scolopendrid (0.3 ml, 1 ml/kg) caused no significant changes in the rCBF and the MABP, whereas BUM (0.3 ml, 1 ml/kg) decreased the rCBF and the MABP, bee venom 25% (0.3 ml, 1 ml/kg) increased the rCBF and lowered the MABP, and sweet bee venom 10% (0.3 ml, 1 ml/kg) increased the rCBF and had no significant effect on the MABP. Conclusions: The rCBF and the MABP were influenced differently by the administration of various pharmacopunctures. Further studies are needed to elucidate the underlying mechanism.

Acknowledgement

Supported by : Wonkwang University

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