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Association of Hemoglobin A1c with Visceral Fat Measured by Computed Tomography in Nondiabetic Adults

당뇨병이 없는 농촌지역의 건강한 성인 남녀에서 당화혈색소와 내장지방과의 관계

  • Han, A Lum (Department of Family Medicine, Hospital of Wonkwang University) ;
  • Shin, Sae-Ron (Department of Family Medicine, Hospital of Wonkwang University) ;
  • Park, Seong-Hoon (Department of Radiology Medicine, Hospital of Wonkwang University) ;
  • Lee, Jeong Mi (Department of Public Health, Wonkwang University Graduate School)
  • 한아름 (원광대학병원 가정의학과) ;
  • 신새론 (원광대학병원 가정의학과) ;
  • 박성훈 (원광대학병원 진단방사선과) ;
  • 이정미 (원광대학교 대학원 보건학과)
  • Received : 2012.06.20
  • Accepted : 2012.10.17
  • Published : 2012.12.31

Abstract

Objective: A prediabetes hemoglobin A1c (HbA1c) level of 5.7%-6.4% is considered a risk factor for diabetes mellitus and cardiovascular disease (CVD) in the USA. In this study, we assessed the HbA1c and visceral fat levels as CVD risk factors in health check-up examinees who were not yet diagnosed with diabetes. Methods: Totally, 507 study subject were categorized as per criteria of the American Diabetes Association, depending on whether the HbA1c level was ${\geq}5.7%$ or <5.7%. Lipid levels, blood pressure, BMI (kg/$m^2$), total abdominal, and visceral fat levels were measured by computed tomography. Results: The mean of HbA1c in the male group was larger than the mean in the female group and their values were, respectively, $6.03{\pm}0.82%$ and $5.88{\pm}0.72%$(p<0.05). Only the mean values of age and visceral fat area were different between $HbA1c{\geq}5.7%$ and <5.7% in both male and female group(p<0.05). Visceral fat levels were significantly associated with HbA1c in the group of HbA1c ${\geq}5.7%$ (odds ratio=1.005, 95% CI 1.002~1.008). Conclusions: Visceral fat levels were significantly higher and correlated with the group which HbA1c level is ${\geq}5.7%$. This finding suggests that subjects who have high levels of HbA1c should be carefully monitored during prediabetes and should have chance to have health education programs.

Keywords

Hemoglobin A1c;Visceral fat;Prediabetes

Acknowledgement

Supported by : 원광대학교

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