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Phenethyl Isothiocyanate Inhibits Ovalbumin-induced Inducible Nitric Oxide Synthase Expression

Ovalbumin에 의해서 유도된 inducible nitric oxide synthase 발현에 대한 phenethyl isothiocyanate의 억제효과

  • Shin, Hwa-Jeong (Department of Medical Science, College of Medical Sciences, Soonchunhyang University) ;
  • Youn, Hyung-Sun (Department of Medical Science, College of Medical Sciences, Soonchunhyang University)
  • 신화정 (순천향대학교 의료과학대학 의료과학과) ;
  • 윤형선 (순천향대학교 의료과학대학 의료과학과)
  • Received : 2012.08.01
  • Accepted : 2012.09.14
  • Published : 2012.12.31

Abstract

Egg allergies have been reported as one of the most prevalent food hypersensitivities in the pediatric population. One of the major egg allergens is ovalbumin (OVA), which is the major protein in the egg whites. Phenethyl isothiocyanate (PEIC) from cruciferous vegetables has an effect on anti-inflammatory therapy. In the present report, we show that PEIC inhibits the nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activation induced by OVA. PEIC also inhibits the OVA-induced inducible nitric oxide synthase (iNOS) expression and nitrite production. However, PEIC did not suppress the cyclooxygenase-2 (COX-2) expression induced by OVA. These results suggest that PEIC has the specific mechanism for anti-inflammatory responses and efficient anti-allergic activities.

Keywords

egg allergy;inducible nitric oxide synthase;NF-${\kappa}B$;ovalbumin;phenethyl isothiocyanate

Acknowledgement

Supported by : 순천향대학교

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