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Antithrombotic Effect and Antiplatelet Activity of Polygonum cuspidatum Extract

호장근 추출물의 항혈전 효능 및 혈소판 응집 억제작용

  • Yang, Won-Kyung (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine) ;
  • Sung, Yoon-Young (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine) ;
  • Kim, Ho-Kyoung (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine)
  • 양원경 (한국한의학연구원 한약기초연구그룹) ;
  • 성윤영 (한국한의학연구원 한약기초연구그룹) ;
  • 김호경 (한국한의학연구원 한약기초연구그룹)
  • Received : 2011.10.17
  • Accepted : 2012.01.06
  • Published : 2012.02.29

Abstract

We performed this study to develop antithrombotic agents from oriental medicine herb extracts. Polygonum cuspidatum has been traditionally used as an edible medical resources for the treatment of cancer, pyodermatitis, hepatitis, cystitis, and inflammation. However, the effects of Polygonum cuspidatum on thrombosis and platelet activation are not precisely understood. The antithrombotic and antiplatelet activities of Polygonum cuspidatum were investigated by assessing the effect of a 70% ethanol extract of Polygonum cuspidatum on blood coagulation, fibrinolysis, and platelet aggregation. Polygonum cuspidatum showed effective fibrinolytic activity at 10 mg/mL. Polygonum cuspidatum also inhibited adenosine diphosphate induced platelet aggregation. Furthermore, evaluation of anticoagulant activity showed that an extract of Polygonum cuspidatum prolonged coagulation time via activated partial thromboplastin time (APTT). Our results show that Polygonum cuspidatum can be a potential candidate for antiplatelet activity as well as a fibrinolytic agent.

Acknowledgement

Supported by : 한국한의학연구원

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