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The Aqueous Extract of Rubus coreanus Miquel Improves Scopolamine-Induced Memory Impairment in ICR Mice

마우스에서 복분자 물추출물의 기억력 감퇴에 대한 개선 효과

  • Choi, Mi-Ran (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Lee, Min-Young (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Hong, Ji-Eun (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Lee, Jae-Yong (Dept. of Biochemistry, College of Medicine, Hallym University) ;
  • Chun, Jang-Woo (Research and Development Center, Hitejinro Co., Ltd.) ;
  • Kim, Tae-Hwan (Research and Development Center, Hitejinro Co., Ltd.) ;
  • Shin, Hyun-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Kim, Eun-Ji (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
  • 최미란 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 이민영 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 홍지은 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 이재용 (한림대학교 의과대학 생화학교실) ;
  • 전장우 (하이트진로주식회사 중앙연구소) ;
  • 김태환 (하이트진로주식회사 중앙연구소) ;
  • 신현경 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 김은지 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터)
  • Received : 2011.11.15
  • Accepted : 2011.12.27
  • Published : 2012.02.29

Abstract

In the present study, we examined the effect of the aqueous extract of Rubus coreanus Miquel (RCM-Ex) on scopolamine-induced memory impairment in male ICR mice. Mice were fed the diet containing 100 mg/kg body weight/day of RCM-Ex for 4 weeks. To induce amnesia, scopolamine (an antagonist of muscarinic acetylcholine receptor, 1 mg/kg of body weight) was intraperitoneally injected into mice 30 min before starting the behavior tests. RCM-Ex reversed scopolamine-induced memory impairments in mice as evidence by the passive avoidance test and Morris water maze test. In addition, acetylcholineasterase activities were decreased in the brains of mice treated with RCM-Ex. These results suggest that RCM-Ex may be an effective agent for the prevention of the memory impairment induced by cholinergic dysfunction.

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