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Effect of Ethanol Extracts of Youngia denticulata and Youngia sonchifolia on the Serum and Hepatic Lipids and Activities of Ethanol Metabolizing Enzymes in Acute Ethanol-Treated Rats

이고들빼기 및 고들빼기 에탄올 추출물 첨가식이가 급성 에탄올 투여 흰쥐의 혈청과 간지질 및 알코올 대사 효소활성 변동에 미치는 영향

  • Son, Jin-Chang (Gyeongsangbuk-do Government Public Institute of Health and Environment) ;
  • Kim, Sung-Hwan (Gyeongsangbuk-do Government Public Institute of Health and Environment) ;
  • Lee, Sang-Il (Dept. of Food, Nutrition & Culinary Arts, Keimyung College University) ;
  • Lee, Ye-Kyung (Division of Bioscience and Bioinformatics, Myongji University) ;
  • Kim, Soon-Dong (Division of Bioscience and Bioinformatics, Myongji University)
  • 손진창 (경상북도 보건환경연구원) ;
  • 김성환 (경상북도 보건환경연구원) ;
  • 이상일 (계명문화대학 식품영양조리학부) ;
  • 이예경 (명지대학교 생명과학정보학부) ;
  • 김순동 (명지대학교 생명과학정보학부)
  • Received : 2011.11.16
  • Accepted : 2011.12.21
  • Published : 2012.02.29

Abstract

This study examined the protective effects of an ethanol extract of Youngia denticulata leaf (YDL) and Youngia denticulata root (YDR), and Youngia sonchifolia leaf (YSL) and Youngia sonchifolia root (YSR) on acute ethanol-intoxicated rat. The rats were pretreated with an ethanol extract of YDL, YDR, YSL and YSR for 4 weeks before being exposed to ethanol (5 g ethanol, po/kg BW). The biochemical indices (hepatic alcohol metabolic enzymes and serum ALT activities, and hepatic and serum lipid profiles) were examined to evaluate the protective effects. The hepatic ADH activities in all experimental groups were not changed significantly by acute ethanol after a pretreatment with the YS and YD ethanol extracts. In contrast, the ALDH activity in EC (ethanol control) was higher than that of NC (normal control); these activities in the YDL and YSL groups were significantly higher than that of the EC group. On the other hand, acute ethanol exposure resulted in a significant increase in the serum TG, total cholesterol, LDL-cholesterol, hepatic TG, total lipid and cholesterol levels, and serum ALT activity, and a decrease in the serum HDL-cholesterol. A pretreatment with the YS and YD ethanol extracts dramatically attenuated these adverse effects. In particular, the YDL pretreatment markedly suppressed the ethanol-induced increase in the serum and hepatic TG and total cholesterol levels. Furthermore, serum ethanol was decreased by a pretreatment with YSL, YSR, YDL, or YDR. Overall, YD and YS ethanol extracts attenuate acute ethanol-induced hyperlipidemia and fatty liver significantly. Nevertheless, further study will be needed.

Keywords

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