A Study on Life Changes of Oral Lichen Planus Patients by SRRS

SRRS를 이용한 구강 편평태선 환자의 생활변화에 관한 연구

  • Ko, Myung-Yun (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Park, Su-Hyeon (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ok, Su-Min (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Huh, Joon-Young (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ahn, Yong-Woo (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Jeong, Sung-Hee (Department of Oral Medicine, School of Dentistry, Pusan National University)
  • 고명연 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 박수현 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 옥수민 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 허준영 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 안용우 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 정성희 (부산대학교 치의학전문대학원 구강내과학 교실)
  • Received : 2012.01.16
  • Accepted : 2012.02.20
  • Published : 2012.03.30


Lichen planus is a chronic inflammatory mucocutaneous disease that affects multiple sites of the body. Often it involves the oral mucosa, but also involve other sites such as skin, genitals, scalp and nails. There is no clear cause of oral lichen planus (OLP), current data suggest that OLP is a T-cell mediated autoimmune disorder which may have an altered self-peptide triggering apoptosis of oral epithelial cells. Usually OLP appears in middle-aged women which tends to be chronic with periods of exacerbation and remission. There are many theories those causes the OLP such as psychological and environmental factors, genetic tendency, drugs and more. 60-70% of lichen planus is accompanied by oral lesions, and more than half of its cases are not able to defined by their skin. In this study, among all the possibility(possible) theories, we tried to evaluate the influence of emotional stress in exacerbating OLP. There were thirty patients with a clinical or histological diagnosis of OLP and other thirty subjects who did not show any signs of systemic disorders include OLP. They were evaluated by using modified Holmes and Rahe's Social Readjustment Rating Scale (SRRS). As a result, a significantly higher level of stress was found in the OLP patients than the control group. Therefore it could be concluded that psychological stressors play an important role in the exacerbating OLP.


Supported by : 부산대학교병원


  1. M. R. Roopashree, Rajesh V Gondhalekar, M. C. Shashikanth, Jiji George, S. H. Thippeswamy, Abhilasha Shukla. Pathogenesis of oral lichen planus - a review. J Oral Pathol Med 2010;39:729-734.
  2. Scully C, Eisen D, Carrozzo M. Management of oral lichen planus. Am J Clin Dermatol 2000;1:287-306.
  3. Petruzzi M, De Benedittis M, Grassi R, Cassano N, Vena G, Serpico R. Oral lichen planus: a preliminary clinical study on treatment with tazarotene. Oral Dis 2002;8:291-295.
  4. KG Sen, RM Hira, AZMM Islam, SK Sarker, MN Sarker, AK Biswas. Effects of Griseofulvin in the Treatment of Lichen Planus -A Study in BSMMU. Faridpur Med. Coll. J 2011;6(2):86-88
  5. Chopra A, Mittal RR, Kaur B. Dapsone versus corticosteroids in lichen planus. Indian J Dermatol Venereol Leprol 1999;65(2):66-68.
  6. Verma KK, Mittal R, Manchanda Y. Azathioprine for the treatment of severe erosive oral and generalized lichen planus. Acta Derm Venereol 2001;81(5):378-379.
  7. Elad S, Epstein JB, Yarom N, Drucker S, Tzach R, von Bültzingslöwen I. Topical immunomodulators for management of oral mucosal conditions, a systematic review; part I: calcineurin inhibitors. Expert Opin Emerg Drugs 2010 Dec;15(4):713-726.
  8. Georgakopoulou EA, Troupis TG, Troupis G, Gorgoulis VG. Update of the cancer-associated molecular mechanisms in oral lichen planus, a disease with possible premalignant nature. J BUON 2011;16(4):613-616.
  9. Bombeccari GP, Guzzi G, Tettamanti M, et al. Oral lichen planus and malignant transformation: a longitudinal cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112(3):328-334.
  10. Shen ZY, Liu W, Feng JQ, Zhou HW, Zhou ZT. Squamous cell carcinoma development in previously diagnosed oral lichen planus: de novo or transformation? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112(5):592-596.
  11. Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2. Clinical management and malignant transformation, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:164-178.
  12. Wilson E. On Lichen Planus. J Cutaneous Medicine 1869;3:117-132.
  13. Hampf BG, Malmstrom MJ, Aalberg VA, Hannula JA, Vikkula J. Psychiatric disturbance in patients with oral lichen planus. Oral Surg Oral Med Oral Pathol 1987;63:429-432.
  14. Rojo-Moreno JL, Bagan JV, Rojo-Moreno J, Donat JS, Milian MA, Jimenez Y. Psychologic factors and oral lichen planus: a psychometric evaluation of 100 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:687-691.
  15. Allen CM, Beck FM, Rossie KM, Kaul TJ. Relation of stress and anxiety to oral lichen planus. Oral Surg Oral Med Oral Pathol 1986;61:44-46.
  16. Holmes TH, Rahe RH,. The social readjustment rating scale. J Psychosom. Res 1967;11:213-217.
  17. 백기청, 홍강의. 스트레스 요인으로서의 생활사건과 통재소재 빛 불안의 관계에 대한 연구. 신경정신의학회지 1987;78(1):75-77.
  18. Wyler AR, Masuda M, Holmes T.H. Magnitude of life events and serious of illness. Psychosom Med 1967;33:115-117.
  19. 고병학, 송옥헌, 신윤오. 한국인의 생활사건에 관한 예비적 연구. 신경정신의학회지 1981;20(1):62-63.
  20. 최태진, 강병조. 한국에서의 사회 재적응평가척도에 관한 예비적 연구. 신경정신의학회지 1981;55(2):131-132.
  21. 홍강의, 정도언. 사회 재적응평가척도 제작. 신경정신의학회지 1982;21(1):123-135.
  22. 이평숙. 생활사건과 관련된 스트레스양 측정에 관한 방법론적 연구. 연세대학교 박사학위논문집 1984;1-138.
  23. 조대경, 이관용, 김기중. 정신위생, 초판, 서울, 1984, 중앙적성출판부, pp.75-101.
  24. 고명연, 옥수민, 권경민, 태일호, 안용우. SRRS를 이용한 BMS 환자의 생활변화에 관한 연구. 대한구강내과학회지 2009;34:189-195
  25. 정현숙, 강규숙, 황애란. 정신 사회적 스트레스와 스트레스질환. 대한간호 1988;26(5) 25-28
  26. Chaudhary S. Psychosocial stressors in oral lichen planus. Aust Dent J 2004 Dec;49(4):192-5.
  27. Bajaj DR, Khoso NA, Devrajani BR, Matlani BL, Lohana P. Oral lichen planus: a clinical study. Coll Physicians Surg Pak 2010;20(3):154-7.
  28. Vallejo MJ, Huerta G, Cerero R, Seoane JM. Anxiety and depression as risk factors for oral lichen planus. Dermatology 2001;203(4):303-7.
  29. Stein S, Hart DL, Loft G, Davis H. Symptoms of TMJ dysfunction or related to stress measured by the social readjustment rating scale. J Prosthet Dent 1982;47:545-546.
  30. L Manolache, D Seceleanu-Petrescu, V Benea. Lichen planus patients and stressful events. J Eur Acad Dermatol Venereol 2008;22(4) 437-441