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Gas Chromatography-High Resolution Tandem Mass Spectrometry Using a GC-APPI-LIT Orbitrap for Complex Volatile Compounds Analysis

  • Lee, Young-Jin (Department of Chemistry, Iowa State University) ;
  • Smith, Erica A. (Department of Chemistry, Iowa State University) ;
  • Jun, Ji-Hyun (Department of Chemistry, Iowa State University)
  • Received : 2012.06.08
  • Accepted : 2012.06.17
  • Published : 2012.06.28

Abstract

A new approach of volatile compounds analysis is proposed using a linear ion trap Orbitrap mass spectrometer coupled with gas chromatography through an atmospheric pressure photoionization interface. In the proposed GC-HRMS/MS approach, direct chemical composition analysis is made for the precursor ions in high resolution MS spectra and the structural identifications were made through the database search of high quality MS/MS spectra. Successful analysis of a complex perfume sample was demonstrated and compared with GC-EI-Q and GC-EI-TOF. The current approach is complementary to conventional GC-EI-MS analysis and can identify low abundance co-eluting compounds. Toluene co-sprayed as a dopant through API probe significantly enhanced ionization of certain compounds and reduced oxidation during the ionization.

References

  1. Kitson, F. G.; Larsen, B. S.; McEwen, C. N. Gas Chromatography and Mass Spectrometry, a Practical Guide; Academic Press, New York, 1996.
  2. Veriotti, T.; Sacks, R. Anal. Chem. 2001, 73, 4395. https://doi.org/10.1021/ac010239d
  3. Luo, Z.; Heffner, C.; Solouki, T. J. Chromatogr. Sci. 2009, 47, 75. https://doi.org/10.1093/chromsci/47.1.75
  4. Peterson, A. C.; McAlister, G. C.; Quarmby, S. T.; Griep- Raming, J.; Coon, J. J. Anal. Chem. 2010, 82, 8618. https://doi.org/10.1021/ac101757m
  5. Luosujärvi, L.; Haapala, M.; Thevis, M.; Saarela, V.; Franssila, S.; Ketola, R. A.; Kostiainen, R.; Kotiahoa, T. J. Am. Soc. Mass Spectrom. 2010, 21, 310. https://doi.org/10.1016/j.jasms.2009.10.019
  6. Stein, S. E. J. Am. Soc. Mass Spectrom.1994, 5, 316. https://doi.org/10.1016/1044-0305(94)85022-4
  7. Horning, E. C.; Horning, M. G.; Carroll, D. I.; Dzidic, I.; Stillwell, R. N. Anal. Chem. 1973, 45, 936. https://doi.org/10.1021/ac60328a035
  8. Mitchum, R. K.; Korfmacher, W. A.; Moler, G. F.; Stalling, D. L. Anal. Chem. 1982, 54, 719. https://doi.org/10.1021/ac00241a028
  9. McEwen, C. E.; McKay, R. G. J. Am. Soc. Mass Spectrom. 2005, 16, 1730. https://doi.org/10.1016/j.jasms.2005.07.005
  10. McEwen, C. E. Int. J. Mass Spectrom. 2007, 259, 57. https://doi.org/10.1016/j.ijms.2006.07.004
  11. Bristow, T.; Harrison, M.; Sims, M. Rapid Commun. Mass Spectrom. 2010, 24, 1673. https://doi.org/10.1002/rcm.4557
  12. Carrasco-Pancorbo, A.; Nevedomskaya, E.; Arthen- Engeland, T.; Zey, T.; Zurek, G.; Baessmann, C.; Deelder,A. M.; Mayboroda, O. A. Anal. Chem. 2009, 81, 10071. https://doi.org/10.1021/ac9006073
  13. Portoles, T.; Sancho, J. V.; Hernandez, F.; Newtonb, A.; Hancock, P. J. Mass. Spectrom. 2010, 45, 926. https://doi.org/10.1002/jms.1784
  14. Muller, A.; Düchting, P.; Weiler, E. W. Planta 2002, 216, 44. https://doi.org/10.1007/s00425-002-0866-6
  15. Haas, W.; Faherty, B. K.; Gerber, S. A.; Elias, J. E.; Beausoleil, S. A.; Bakalarski, C. E.; Li, X.; Villen, J.; Gygi, S. P. Mol. Cell. Proteomics 2006, 5, 1326. https://doi.org/10.1074/mcp.M500339-MCP200
  16. Makarov, A.; Denisov, E.; Lange, O.; Horning, S. J. Am. Soc. Mass Spectrom. 2006, 17, 977. https://doi.org/10.1016/j.jasms.2006.03.006
  17. Fjeldsted, J. Time-of-Flight Mass Spectrometry, Technical Overview; Report 5989-0373EN, Agilent Technologies: 2003.
  18. Heinonena, M.; Rantanena, A.; Mielikainena, T.; Pitkänena, E.; Kokkonenb, J.; Rousua, J. German Conference on Bioinformatics GCB, p. 40-53, 2006.
  19. Lutisan, J.; Huang, Y.; Nikiforov, A.; Suchy, M.; Mistrik, R. ThOEam 09:30, May 27, 58th ASMS Conference on Mass Spectrometry, Salt Lake City, Utah, May 23-27, 2010.
  20. Revelsky, I. A.; Yashin, Y. G.; Sobolesvsky, T. G.; Revelsky, A. I. Eur. J. Mass Spectrom. 2003, 9, 497. https://doi.org/10.1255/ejms.581
  21. McLafferty, F. W.; Turecek, F.: Interpretation of Mass Spectra, 4th ed., University Science Books, Mill Valley, 1993.
  22. Prasain, J. K.; Moore, R.; Hurst, J. S.; Barnes, S.; Frederik, F. J. G. M. J. Mass Spectrom. 2005, 40, 916. https://doi.org/10.1002/jms.868
  23. Olsen, J. V.; de Godoy, L. M. F.; Li, G.; Macek, B.; Mortensen, P.; Pesch, R.; Makarov, A.; Lange, O.; Horning, S.; Mann, M. Mol. Cell. Proteomics 2005, 4, 2010. https://doi.org/10.1074/mcp.T500030-MCP200
  24. Kind, T.; Fiehn, O. BMC Bioinformatics 2006, 7, 234. https://doi.org/10.1186/1471-2105-7-234
  25. Kind, T.; Fiehn, O. BMC Bioinformatics 2007, 8, 105. https://doi.org/10.1186/1471-2105-8-105
  26. Olsen, J. V.; Macek, B.; Lange, O.; Makarov, A.; Horning, S.; Mann, M. Nat. Methods 2007, 4, 709. https://doi.org/10.1038/nmeth1060

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