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Effect of Lithospermi Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice

  • Kim, Han-Na (Division of Pharmacology, Pusan National University School of Korean Medicine) ;
  • Kim, Mi-Young (Division of Pharmacology, Pusan National University School of Korean Medicine) ;
  • Choi, Chan-Hun (Department of Pathology, College of Oriental Medicine, Dongshin University College of Korean Medicine) ;
  • Kim, Byung-Joo (Division of Pharmacology, Pusan National University School of Korean Medicine) ;
  • Kim, Kyung-Yoon (Department of Physical Theraphy, Dongshin University College of Health and Welfare) ;
  • Kim, Gye-Yeop (Department of Physical Theraphy, Dongshin University College of Health and Welfare) ;
  • Jeong, Hyun-Woo (Department of Pathology, College of Oriental Medicine, Dongshin University College of Korean Medicine) ;
  • Kim, Hyung-Woo (Division of Pharmacology, Pusan National University School of Korean Medicine)
  • Received : 2012.02.27
  • Accepted : 2012.05.30
  • Published : 2012.06.30

Abstract

Objectives: The root of Lithospermum erythrorhizon Sieb. et Zucc. (Lithospermi Radix, LR) is a kind of heat clearing and blood cooling medicinal herbs. It can clear away heat and cool the blood, reduce toxins and disperse maculae. LR has long been used as efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. Methods: In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4- dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model. Results: Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB. Topical application of LR also inhibited hyperplasia, edema, spongiosis and infiltrations of mononuclear cells. In addition, production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo. Conclusions: These data suggest that LR acts as an antiinflammatory agent, improving skin lesions in CD mice.

Acknowledgement

Supported by : National Research Foundation of Korea

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