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The Effects of Yacon (Smallanthus sonchifolius) Extract on Pancreatic Fibrosis in the Rat

야콘(Smallanthus sonchifolius) 추출물이 흰쥐의 췌장 섬유화에 미치는 영향

  • Choi, Nan-Hee (Department of Anatomy, College of Oriental medicine, Dongguk University) ;
  • Kim, Jong-Bong (Department of Medical Life Science, Catholic University of Daegu) ;
  • Kim, Jin-Teak (Department of Anatomy, College of Oriental medicine, Dongguk University) ;
  • Park, In-Sick (Department of Anatomy, College of Oriental medicine, Dongguk University)
  • 최난희 (동국대학교 한의과대학 해부학교실) ;
  • 김종봉 (대구가톨릭대학교 의생명과학과) ;
  • 김진택 (동국대학교 한의과대학 해부학교실) ;
  • 박인식 (동국대학교 한의과대학 해부학교실)
  • Received : 2012.03.06
  • Accepted : 2012.06.17
  • Published : 2012.07.30

Abstract

Yacon has been used in folk medicines as a medicinal tea for hypoglycemia treatment. In a recent study described herein, antioxidative, antibacterial, antifungal activities, and cell-protective functions of yacon leaves have been reported. To evaluate the effects on fibrosis on pancreatitis, the efficacy of 1% of yacon extract (YE) on dibutyltin dichloride (DBTC) (8 mg/kg)-induced pancreatitis in rats was examined. On the 21st day after the DBTC treatment, a large increase in collagen was observed in the pancreas in the DBTC-treatment group (DT). But this was noticeably decreased with YE. In relation to the expression of COX-2, there was no response or a very weak response in the pancreas of the control group (CON). However, in DT, strong expression of COX-2 was observed in the pancreas on the 14th day, and COX-2 was present in inflammatory cells in the pancreas of the DT, especially on the 21st day. The expression was decreased for YE compared with DT. A remarkable increase in TGF-${\beta}1$ expression was observed in inflammatory cells in the pancreas in DT on the 21st day, whereas the expression was not found in YE after 21 days. However, on the 21th day, TGF-${\beta}1$ expression was increased in acinar cells of YE compared with DT. VEGF expression was very similar to the expression of in the pancreas. These results suggest that YE has an inhibitory effect on DBTC-induced pancreatic fibrosis.

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