DOI QR코드

DOI QR Code

Detecting Genetic Association and Gene-Gene Interaction using Network Analysis in Case-Control Study

  • Received : 2012.04.10
  • Accepted : 2012.06.05
  • Published : 2012.08.31

Abstract

Various methods of analysis have been proposed to understand the gene-disease relation and gene-gene interaction effect for a disease through comparison of genotype in case-control study. In this study, we proposed the method to detect a genetic association and gene-gene interaction through the use of a network graph and centrality measures that are used in social network analysis. The applicability of the proposed method was studied through an analysis of real genetic data.

Keywords

Network analysis;genetic association;gene-gene interaction;centrality measures

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Acknowledgement

Supported by : National Research Foundation of Korea (NRF)