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Relationship Between PTEN and Livin Expression and Malignancy of Renal Cell Carcinomas

  • Cheng, Tao (Department of Urology, the 1st Affiliated Hospital of He'nan University of Science and Technology) ;
  • Zhang, Jian-Guo (Department of Urology, the 1st Affiliated Hospital of He'nan University of Science and Technology) ;
  • Cheng, Yuan-He (Department of Urology, the 1st Affiliated Hospital of He'nan University of Science and Technology) ;
  • Gao, Zhong-Wei (Department of Urology, the 1st Affiliated Hospital of He'nan University of Science and Technology) ;
  • Ren, Xiao-Qiang (Department of Urology, the 1st Affiliated Hospital of He'nan University of Science and Technology)
  • Published : 2012.06.30

Abstract

Objectives: This study focused on PTEN and Livin expression and associations with malignancy in human renal clear cell carcinomas (RCCC). Methods: PTEN and Livin expression was assessed in 100 RCCC tissue samples, 50 paracarcinoma cases, and 20 normal renal tissue samples using the immunohistochemical Streptavidin proxidase (SP) method. The relationships between binding and corresponding biological characteristics, such as histological grade, lymph node metastases, and clinical stages were analyzed. Results: Positive PTEN expression in RCCC was significantly lower than in renal tissue adjacent to carcinoma tissue and normal renal tissue (P<0.01). Livin expression in the renal tissue adjacent to the carcinoma and normal renal tissues exhibited only low levels, whereas overall Livin expression in RCCC was statistically significant (P<0.01). In RCCC, PTEN expression rate gradually decreased with an increase in clinical stage, whereas that of Livin increased to statistically significant levels (P<0.01), PTEN and Livin levels being negatively correlated (r=-0.395, P<0.01). Conclusions: PTEN and Livin are important in RCCC development. The two factors combined are expected to provide indices for estimating RCCC malignancy and progression levels, as well as references for RCCC diagnosis and treatment.

Keywords

Renal clear cell carcinoma (RCCC);PTEN;livin;immunohistochemistry

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  2. Association of the PTEN IVS4 (rs3830675) Gene Polymorphism with Reduced Risk of Cancer: Evidence from a Meta-analysis vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.897
  3. MicroRNA-22 is downregulated in clear cell renal cell carcinoma, and inhibits cell growth, migration and invasion by targeting PTEN vol.13, pp.6, 2016, https://doi.org/10.3892/mmr.2016.5101