Four years Incidence Rate of Colorectal Cancer in Iran: A Survey of National Cancer Registry Data - Implications for Screening

  • Azadeh, Safaee (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Science) ;
  • Reza, Fatemi Seyed (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Science) ;
  • Sara, Ashtari (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Science) ;
  • Mohsen, Vahedi (Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science) ;
  • Bijan, Moghimi-Dehkordi (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Science) ;
  • Zali, Zali Reza (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Science)
  • Published : 2012.06.30


Introduction: Design and implementation of screening programs in each country must be based on epidemiological data. Despite the relatively high incidence of CRC, there is no nationwide comprehensive program for screening in Iran. This study was designed to investigate national CRC data and help to determine guidelines for screening. Methods: Incidence data used in this study were obtained from Iranian annual of National Cancer Registration report. Age standardized rates (ASR)were calculated using world standard population and were categorized by age, sex, anatomic subsite and morphology of tumor. Data were analyzed using SPSS.V.13 and Open Source Epidemiologic Statistics for Public Health software (OpenEpi v.2.3.1). Results: A quarter of cases were less than 50 years of age. The majority of tumors were detected in the colon. The overall ASR in the four years period was 38.0 per 100000 and was higher for men compared women (P<0.05). Incidence rate of colorectal cancer increased with age. Conclusion: Results of present study indicated that incidence of colorectal cancer is relatively high in Iran. Incidence of CRC in people under 50 years and in rectum were reported higher than other countries that related etiologic factors should be investigate in further studies. According to the increasing of ASR after age 50 years, it seems that onset of screening at age 50 would be appropriate.


  1. Azadeh S, Moghimi-Dehkordi B, Fatem S R, et al (2008). Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev, 9, 123-6.
  2. Boyle P, Leon M E (2002). Epidemiology of colorectal cancer. Br Med Bull, 64, 1-25.
  3. Chong VH, Abdullah MS, Telisinghe PU, et al (2009). Colorectal cancer: incidence and trend in Brunei Darussalam. Singapore Med J, 50, 1085-9.
  4. De Kok I M, Wong C S, Chia K S, et al (2008). Gender differences in the trend of colorectal cancer incidence in Singapore, 1968-2002. Int J Colorectal Dis, 23, 461-7.
  5. Faivre J, Bouvier A M, Bonithon-Kopp C (2002). Epidemiology and screening of colorectal cancer. Best Pract Res Clin Gastroenterol, 16, 187-99.
  6. Fatemi S R, Shivarani S, Malek F N, et al (2010). Colonoscopy screening results in at risk Iranian population. Asian Pac J Cancer Prev, 11, 1801-4.
  7. Fritz A, Percy C, Jack A, et al 2000. International Classification of Diseases for Oncology, Genova: World Health Organization.
  8. Giddings B H, Kwong S L, Parikh-Patel A, et al (2012). Going against the tide: increasing incidence of colorectal cancer among Koreans, Filipinos, and South Asians in California, 1988-2007. Cancer Causes Control, 23, 691-702.
  9. Haggar F A, Boushey R P (2009). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg, 22, 191-7.
  10. Islamic Repulic of Iran. Ministry of Health and Medical Education. Center for Disease Control & Prevention. Noncommunicable Deputy. Cancer Office (2008-2009). Iranian Annual of National Cancer Registration Report.
  11. Jackson-Thompson J, Ahmed F, German R R, et al (2006). Descriptive epidemiology of colorectal cancer in the United States, 1998-2001. Cancer, 107, 1103-11.
  12. Jiang S X, Wang X S, Geng C H, et al (2009). Altering trend of clinical characteristics of colorectal cancer: a report of 3,607 cases. Ai Zheng, 28, 54-6.
  13. Keyfitz N (1966). Sampling Variance of Standardized Mortality Rates. Human Biology, 38, 309-17.
  14. Moghimi-Dehkordi B, Safaee A, Zali M R (2008). Prognostic factors in 1,138 Iranian colorectal cancer patients. Int J Colorectal Dis, 23, 683-8.
  15. Pahlavan P S, Kanthan, R (2006). The epidemiology and clinical findings of colorectal cancer in Iran. J Gastrointestin Liver Dis, 15, 15-9.
  16. Ponz De Leon M, Rossi G, Di Gregorio C, et al (2007). Epidemiology of colorectal cancer: the 21-year experience of a specialised registry. Intern Emerg Med, 2, 269-79.
  17. Rim S H, Seeff L, Ahmed F, et al (2009). Colorectal cancer incidence in the United States, 1999-2004 : an updated analysis of data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program. Cancer, 115, 1967-76.
  18. Rozen P, Liphshitz I, Barchana M (2012). Changing Epidemiology of Colorectal Cancer Makes Screening Sigmoidoscopy Less Useful for Identifying Carriers of Colorectal Neoplasms. Dig Dis Sci.
  19. Safaee A, Moghimi Dehkordi B, Fatemi S R, et al (2010). Epidemiological Differences between Colon Cancer and Rectum Cancer. Iran J Cancer Prev, 3, 185-92.
  20. Suwanrungruang K, Wiangnon S, Sriamporn S, et al (2006). Trends in incidences of stomach and colorectal cancer in Khon Kaen, Thailand 1985-2004. Asian Pac J Cancer Prev, 7, 623-6.
  21. Tas F, Keskin S (2011). Age-specific incidence ratios of colorectal cancer (CRC) in Turkey: CRC in older people is increasing. Arch Gerontol Geriatr. ??, ??
  22. Yee Y K, Tan V P, Chan P, et al (2009). Epidemiology of colorectal cancer in Asia. J Gastroenterol Hepatol, 24, 1810-6.

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