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Clinical Significance of Basal-like Breast Cancer in Chinese Women in Heilongjiang Province

  • Liu, Ying (Department of Oncology, Second Affiliated Hospital of Harbin Medical University) ;
  • Jiang, Qiu-Ying (Department of Oncology, Second Affiliated Hospital of Harbin Medical University) ;
  • Xin, Tao (Department of Oncology, Second Affiliated Hospital of Harbin Medical University) ;
  • Cai, Li (Department of Oncology, Affiliated Oncology Hospital of Harbin Medical University) ;
  • Zhao, Chang-Hong (Department of Oncology, Affiliated Oncology Hospital of Harbin Medical University)
  • Published : 2012.06.30

Abstract

Background: Our objective was to clarify the clinical and biological characteristics of basal-like breast cancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang. Methods: We examined, by immunohistochemistry, expression of biological markers cytokeratin (CK) 5/6 and epidermal growth factor receptor (EGFR) and B cell specific moloney murine leukemia virus integration site 1( Bmi-1) in triple-negative breast cancer (TNBC). We studied the correlation between BLBC and several factors related to tumor progression, along with its prognostic value. Results: In the 229 cases of operable TNBC, BLBC was detected in 178 (77.7%) and TN3BKE- in 51 (22.2%). There was no significant difference in clinicopathological factors between them, However, BLBC was significantly associated with Bmi-1 expression (P=0.000) and shorter disease-free survival (DFS) (P = 0.045) and overall survival (OS) (P = 0.041). Conclusions: Compared with the non-basal group, patients with BLBC have a high expression of Bmi-1 and a poor prognosis.

Keywords

Basal like;breast cancer;prognosis

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