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Expression and Clinical Significance of STAT3, P-STAT3, and VEGF-C in Small Cell Lung Cancer

  • Zhao, Xue ;
  • Sun, Xian ;
  • Li, Xiao-Li
  • Published : 2012.06.30

Abstract

Objective: To determine STAT3, P-STAT3, and VEGF-C expression levels in small cell lung cancers (SCLCs), and discuss their role and clinical significance in SCLC development. Method: Immunohistochemical methods were applied to 128 cases of SCLC and 40 cases of adjacent normal tissue. Results: The expression levels of STAT3, P-STAT3, and VEGF-C were higher in SCLC than in normal tissue (P<0.05). Pairwise comparisons showed positive correlations with lymph node metastasis, clinical stage, and tumor size (P<0.05). The expression levels were also related with the overall survival rates. Conclusion: STAT3 and VEGF-C play important roles in the development of SCLC, and might be expected to become new targets for SCLC treatment.

Keywords

STAT3;P-STAT3;VEGF-C;SCLC;survival

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