- Volume 13 Issue 6
Objective: To determine STAT3, P-STAT3, and VEGF-C expression levels in small cell lung cancers (SCLCs), and discuss their role and clinical significance in SCLC development. Method: Immunohistochemical methods were applied to 128 cases of SCLC and 40 cases of adjacent normal tissue. Results: The expression levels of STAT3, P-STAT3, and VEGF-C were higher in SCLC than in normal tissue (P<0.05). Pairwise comparisons showed positive correlations with lymph node metastasis, clinical stage, and tumor size (P<0.05). The expression levels were also related with the overall survival rates. Conclusion: STAT3 and VEGF-C play important roles in the development of SCLC, and might be expected to become new targets for SCLC treatment.
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- STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer vol.16, pp.1, 2013, https://doi.org/10.4048/jbc.2013.16.1.40
- STAT3 is associated with lymph node metastasis in gastric cancer vol.34, pp.5, 2013, https://doi.org/10.1007/s13277-013-0837-5
- Serum neuron-specific enolase levels were associated with the prognosis of small cell lung cancer: a meta-analysis vol.34, pp.5, 2013, https://doi.org/10.1007/s13277-013-0896-7
- Luteolin Arrests Cell Cycling, Induces Apoptosis and Inhibits the JAK/STAT3 Pathway in Human Cholangiocarcinoma Cells vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.5071
- Radiation Induces Phosphorylation of STAT3 in a Dose- and Time-dependent Manner vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6161
- Timing of Thoracic Radiotherapy in Limited Stage Small Cell Lung Cancer: Results of Early Versus Late Irradiation from a Single Institution in Turkey vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6263
- Apoptotic Effects of psiRNA-STAT3 on 4T1 Breast Cancer Cells in Vitro vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6977
- S-Phase Cell Cycle Arrest, Apoptosis, and Molecular Mechanisms of Aplasia Ras homolog Member I–Induced Human Ovarian Cancer SKOV3 Cell Lines vol.24, pp.4, 2014, https://doi.org/10.1097/IGC.0000000000000105
- Assessing the Role of STAT3 in DC Differentiation and Autologous DC Immunotherapy in Mouse Models of GBM vol.9, pp.5, 2014, https://doi.org/10.1371/journal.pone.0096318
- Induction of Murine Macrophage M2 Polarization by Cigarette Smoke Extract via the JAK2/STAT3 Pathway vol.9, pp.9, 2014, https://doi.org/10.1371/journal.pone.0107063
- Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation vol.14, pp.1, 2016, https://doi.org/10.1186/s12967-016-0770-7
- The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms vol.8, pp.9, 2016, https://doi.org/10.3390/nu8090581
- Correlation between p-STAT3 overexpression and prognosis in lung cancer: A systematic review and meta-analysis vol.12, pp.8, 2017, https://doi.org/10.1371/journal.pone.0182282
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