- Volume 15 Issue 3
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Study of Single-dose Toxicity of Aconitum Kusnezoffii Reichb. Pharmacopuncture in Rats
- Kim, Jae-Kyoun (Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical Hospital) ;
- Kim, Sung-Ha (Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical Hospital) ;
- Lee, Sang-Mi (Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical Hospital) ;
- Jeong, Ho-Hyun (Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical Hospital) ;
- Park, Man-Yong (Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical Hospital) ;
- Kim, Dong-Woung (Department of Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital) ;
- Song, Bong-Keun (Department of Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital) ;
- Lee, Jong-Deok (Department of Radiology, Wonkwang University College of Korean Medicine) ;
- Kim, Sung-Chul (Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical Hospital)
- Received : 2012.07.27
- Accepted : 2012.09.12
- Published : 2012.09.30
Objective: This study was performed to analyze the single-dose toxicity of Aconitum kusnezoffii Reichb. pharmacopuncture (AKRP). Methods: All experiments were conducted at the Korea Testing & Research Institute (KTRI), an institute authorized to perform non-clinical studies, under the regulations of Good Laboratory Practice (GLP). Twenty (20) Sprague-Dawley rats were chosen for the pilot study. The animals were divided into four groups of five animals per group: group 1 (G1) being the control group with each animal receiving an injection of 0.3 ml of saline and groups 2, 3, and 4 (G2, G3, and G4) being the experimental groups with each animal receiving an injection of 0.1, 0.2 or 0.3 ml of AKRP, respectively. This study was conducted with the approval of the Institutional Animal Ethics Committee. Results: No deaths occurred in any of the 4 groups, and the
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