Minimally Invasive Laser-Assisted Biopsy of the Oral Lesions for Oral Graft-Versus-Host Disease after Hematopoietic Stem-Cell Transplantation

조혈줄기세포이식후 발생한 이식편대숙주병의 구강병소에 대한 최소침습적 레이저조직생검 증례

  • Kim, Yun-Mi (Department of Advanced General Dentistry, College of Dentistry, Yonsei University) ;
  • Yun, Hee-Jung (Department of Advanced General Dentistry, College of Dentistry, Yonsei University) ;
  • Kim, Hyun-Sil (Department of Oral Pathology, College of Dentistry, Yonsei University) ;
  • Kim, Kee-Deog (Department of Advanced General Dentistry, College of Dentistry, Yonsei University) ;
  • Jung, Bock-Young (Department of Advanced General Dentistry, College of Dentistry, Yonsei University) ;
  • Pang, Nan-Sim (Department of Advanced General Dentistry, College of Dentistry, Yonsei University) ;
  • Park, Won-Se (Department of Advanced General Dentistry, College of Dentistry, Yonsei University)
  • 김윤미 (연세대학교 치과대학 통합진료학과) ;
  • 윤희정 (연세대학교 치과대학 통합진료학과) ;
  • 김현실 (연세대학교 치과대학 구강병리학교실) ;
  • 김기덕 (연세대학교 치과대학 통합진료학과) ;
  • 정복영 (연세대학교 치과대학 통합진료학과) ;
  • 방난심 (연세대학교 치과대학 통합진료학과) ;
  • 박원서 (연세대학교 치과대학 통합진료학과)
  • Received : 2012.04.20
  • Accepted : 2012.07.25
  • Published : 2012.09.30


Hematopoietic stem-cell transplantation (HSCT) is a treatment for immune deficiency, autoimmune diseases, and hematopoietic malignancies. The main complication of allogenic HSCT is graft-versus-host disease (GVHD). Oral mucosal biopsy is needed for a definitive diagnosis and treatment planning of GVHD, but this procedure causes bleeding and bacteremia in a poor general condition. We evaluated the efficacy of laser-assisted biopsy as a minimally invasive treatment. Three cases were described in this article. All patients' medical records, clinical photographs, and histopathologic findings were reviewed. All patients felt comfortable and no severe complications occurred. The quality of the obtained biopsy material was adequate for a definitive diagnosis of GVHD. Laser-assisted, minimally invasive biopsy of the oral mucosa does not cause bleeding, and it reduces the chances of infection, bacteremia, and postoperative scarring compared to the usual histopathologic biopsy procedure. It would thus be advantageous to use this procedure to biopsy GVHD patients.


Supported by : National Research Foundation of Korea (NRF)


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