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A New Treatment Modality Using Topical Sulfasalazine for Oral Lichen Planus

구강편평태선에 대한 sulfasalzine의 국소적용

  • Jeong, Sung-Hee (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Park, Su-Hyeon (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ok, Soo-Min (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Heo, Jun-Young (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ko, Myung-Yun (Department of Oral Medicine, School of Dentistry, Pusan National University) ;
  • Ahn, Yong-Woo (Department of Oral Medicine, School of Dentistry, Pusan National University)
  • 정성희 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 박수현 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 옥수민 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 허준영 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 고명연 (부산대학교 치의학전문대학원 구강내과학교실) ;
  • 안용우 (부산대학교 치의학전문대학원 구강내과학교실)
  • Received : 2012.08.17
  • Accepted : 2012.09.13
  • Published : 2012.09.30

Abstract

Background Oral lichen planus (OLP) is a chronic inflammatory disease characterized by cell-mediated immune responses, but the exact cause is unknown. Sulfasalazine has shown efficacy in the treatment of cutaneous lichen planus. Objective Our purpose was to assess the usefulness of sulfasalazine in treatment of OLP resistant to corticosteroid therapy. This study provides a new option for controlling OLP symptoms. Methods Two patients with the symptomatic reticular form of OLP were treated with 30 mg/5 ml of topical sulfasalazine for 8 to 15 weeks and were evaluated for symptom severity using a numerical analog scale during each week of treatment. The lesion size was measured using a 2 $mm^2$ grid. Results After 2 weeks of application, both patients reported improvements in their symptoms and lesions. Most of the lesions disappeared after 8 weeks of treatment without any side effects. Conclusion Topical sulfasalazine can be a successful treatment option for patients with oral lichen planus resistant to steroid therapy.

Acknowledgement

Supported by : Pusan National University Hospital

References

  1. Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: A study of 723 patients. J Am Acad Dermatol 2002; 46: 207-214. https://doi.org/10.1067/mjd.2002.120452
  2. Demitsu T, Sato T, Inoue T, et al. Corticosteroidresistant erosive oral lichen planus successfully treated with topical cyclosporine therapy. Int J Dermatol 2000; 39: 79-80. https://doi.org/10.1046/j.1365-4362.2000.00863.x
  3. Edwards PC, Kelsch R. Oral lichen planus: Clinical presentation and management. J can Dent Assoc 2002; 68: 494-499.
  4. Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: Facts and controversies. Clin Dermatol 2010; 28: 100-108. https://doi.org/10.1016/j.clindermatol.2009.03.004
  5. el-Mofty M, el-Darouti M, Rasheed H, et al. Sulfasalazine and pentoxifylline in psoriasis: A possible safe alternative. J Dermatolog Treat 2011; 22: 31-37. https://doi.org/10.3109/09546630903460260
  6. Rashidi T, Mahd AA. Treatment of persistent alopecia areata with sulfasalazine. Int J Dermatol 2008; 47: 850-852. https://doi.org/10.1111/j.1365-4632.2008.03700.x
  7. Bauza A, Espana A, Gil P, et al. Successful treatment of lichen planus with sulfasalazine in 20 patients. Int J Dermatol 2005; 44: 158-162. https://doi.org/10.1111/j.1365-4632.2005.02070.x
  8. Omidian M, Ayoobi A, Mapar M, et al. Efficacy of sulfasalazine in the treatment of generalized lichen planus: Randomized double-blinded clinical trial on 52 patients. J Eur Acad Dermatol Venereol 2010; .
  9. McGirt LY, Vasagar K, Gober LM, et al. Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Arch Dermatol 2006; 142: 1337- 1342.