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Anti-oxidant activities of kiwi fruit extract on carbon tetrachloride-induced liver injury in mice

  • Kang, Wonyoung (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Yang, Heekyoung (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Hong, Hyun Ju (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Han, Chang Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Lee, Young Jae (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 투고 : 2012.02.16
  • 심사 : 2012.11.27
  • 발행 : 2012.12.31

초록

The kiwi (Actinidia deliciosa) is well known to contain anti-oxidants. In this study, we investigated the anti-oxidant effects of kiwi extract on carbon tetrachloride ($CCl_4$) induced liver injury in BALB/c mice. The radical scavenging effect of 80% methanol extract of Halla-Gold kiwi was observed. For the animal study, mice were randomly divided into four groups: normal group, $CCl_4$-induced model group, kiwi extract administered group, and silymarin treated group. The kiwi extract was provided daily for 10 days. At the 24 h after last administration, $CCl_4$ was injected. The kiwi extract showed strong inhibitory effect of DPPH radicals and superoxide scavenging. In animal study, administration of $CCl_4$ resulted in significantly elevated plasma levels of ALT and AST but they decreased in kiwi-extract pretreated group. Anti-oxidant enzymes such as GSH-px and GSH-rd were restored in the kiwi extract treatment group. Histopathological degeneration was also prevented in the kiwi extract treated group compared with of the control group, which exhibited $CCl_4$-induced hepatotoxicity. On the basis of the obtained results, it can be concluded that kiwi extract showed protective effects, not only as anti-oxidant effects, but also in the protection of hepatotoxicity in $CCl_4$-intoxicated mice.

과제정보

연구 과제 주관 기관 : Rural Development Administration

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