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An immunohistochemical study on the initial development of 155 kd neurofascin in rat sciatic nerve

랫드 궁둥신경에서 155 kd Neurofascin의 발현개시에 대한 면역세포화학적연구

  • Won, Hee-Young (College of Veterinary Medicine and Veterinary Research Institute, Konkuk University) ;
  • Cho, Ik-Hyun (School of Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Jong-Hwan (College of Veterinary Medicine and Veterinary Research Institute, Konkuk University) ;
  • Nahm, Sang-Soep (College of Veterinary Medicine and Veterinary Research Institute, Konkuk University) ;
  • Choe, Nong-Hoon (College of Veterinary Medicine and Veterinary Research Institute, Konkuk University) ;
  • Park, Jae-Hyung (School of Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Chang, Byung-Joon (College of Veterinary Medicine and Veterinary Research Institute, Konkuk University)
  • 원희영 (건국대학교 수의과대학 및 수의과학연구소) ;
  • 조익현 (경희대학교 한의과대학) ;
  • 이종환 (건국대학교 수의과대학 및 수의과학연구소) ;
  • 남상섭 (건국대학교 수의과대학 및 수의과학연구소) ;
  • 최농훈 (건국대학교 수의과대학 및 수의과학연구소) ;
  • 박재형 (대원국제중학교) ;
  • 장병준 (건국대학교 수의과대학 및 수의과학연구소)
  • Received : 2012.08.13
  • Accepted : 2012.09.25
  • Published : 2012.09.30

Abstract

Neurofascin, one of the members of L1CAM, has been known to have some important roles during the development of nerve fibers. In order to investigate the role of neurofascin associated with the development of nerve fibers in the rat sciatic nerve, the initial development of NF155 in the paranode was studied with immuno-fluorescence and immuno-electron microscopy. The result of the present study showed NF155 was not detected in the fetal sciatic nerve and began to reveal at the postnatal day 0 (P0) and dramatically increased by time lapse until postnatal day 7 (P7). NF155 was prominently localized in the axolemma of paranode and not detected in the central region of node of Ranvier. According to the present study, NF155 is likely to have some relationships with the formation of paranode and myelin sheath.

Acknowledgement

Supported by : 건국대학교