Antinociceptive and Anti-inflammatory Properties of Cinnamomum cassia Derived-cinnamaldehyde in Rodents

육계 유래 Cinnamaldehyde의 투여와 항염증 및 진통효과의 평가

  • Je, Hyun-Dong (Department of Pharmacology, College of Pharmacy, Catholic University of Daegu)
  • 제현동 (대구가톨릭대학교 약학대학 약물학교실)
  • Received : 2012.05.23
  • Accepted : 2012.07.27
  • Published : 2012.08.31


The aim of present study was to investigate the possible influence and the related mechanism of Cinnamomum cassia derived-cinnamaldehyde on the inflammation or nociception. Cinnamomum cassia was referred to be treated for common cold or dyspepsia in the traditional medicine. However, there are no reports on the antinociceptive or anti-inflammatory properties of cinnamaldehyde, the primary ingredient of Cinnamomum cassia. We hypothesized that cinnamaldehyde would play a role in the modulation of inflammation or nociception evoked by carrageenan, acetic acid or heat. Male Institute of Cancer Research mice were used and the size of edema, frequency of writhing and latency of abnormal behaviors such as licking, flicking, shaking or jumping were measured and recorded. The present study was carried out to evaluate the antiinflammatory and antinociceptive effects of cinnamaldehyde. The administration of cinnamaldehyde (30 and 100 mg/kg) inhibited carrageenan-induced paw edema only at the final phase, suggesting the blockade of synthesis or release of prostaglandins. It also reduced the frequency of the acetic acid-induced writhing reflex in mice. In addition, the administration of cinnamaldehyde prolonged the latency for extraordinary reaction at the hot plate in mice. In conclusion, cinnamaldehyde has anti-inflammatory and analgesic properties and is a potential therapeutic for inflammation and nociception.


  1. Schmid-Schonbein, G. W. : Analysis of inflammation. Annu. Rev. Biomed. Eng. 8, 93 (2006).
  2. Brenner, P. S. and Krakauer, T. : Regulation of inflammation: A review of recent advances in anti-inflammatory strategies. Curr. Med. Chem. Anti-Inflamm. Anti-Allergy Agents 2, 274 (2003).
  3. Hansson, G. K. : Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352, 1685 (2005).
  4. Merskey, H. : The definition of pain. Eur. Psychiat. 6, 153 (1991).
  5. Argoff, C. E. : The coexistence of neuropathic pain, sleep, and psychiatric disorders: novel treatment approach. Clin. J. Pain 23, 15 (2007).
  6. Fishbain, D. A. : Approaches to treatment decisions for psychiatric comorbidity in the management of the chronic pain patient. Med. Clin. N. Am. 83, 737 (1999).
  7. Derle, D. V., Gujar, K. N. and Sagar, B. S. H. : Adverse effects associated with the use of nonsteroidal antiinflammatory drugs: An overview. Indian J. Pharm. Sci. 64, 409 (2006).
  8. MacPherson, R. D. : The pharmacological basis of contemporary pain management. Pharmacol. Ther. 88, 163 (2000).
  9. Sanchez-Borges, M. : NSAID Hypersensitivity (Respiratory, Cutaneous, and Generalized Anaphylactic Symptoms). Medical Clinics of North America 94, 853 (2010).
  10. Darland, T., Heinricher, M. M. and Grandy, D. K. : Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more. Trends Neurosci. 21, 215 (1998).
  11. Yang, L., Zhao, Q., Tan, J., Shang, Z. and Du, Z. : Studies on chemical constituents of Ramulus Cinnamomi. Practical Pharmacy and Clinical Remedies 13, 183 (2010).
  12. Cabello, C. M., Bair, W. B., Lamore, S. D., Ley, S., Bause, A. S., Azimian, S. and Wondrak, G. T. : The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic. Biol. Med. 46, 220 (2009).
  13. Di Rosa, M. and Willoughby, D. A. : Screens for antiinflammatory drugs. J. Pharmacy Pharmacol. 23, 297 (1971).
  14. Vinegar, R., Schreiber, W. and Hugo, R. : Biphasic development of carrageenin edema in rats. J. Pharmacol. Exp. Ther. 166, 96 (1969).